Although the pathogenesis of ankylosing spondylitis (AS), which is a systemic disease characterized by inflammation, largely unknown, pro-inflammatory mediators, oxidative stress, and immunity are thought to be involved in development prognosis disease. It was aimed this study reveal activities adenosine deaminase (ADA), cornerstone enzyme different pathways. Twenty nine AS patients 16 healthy ...

Numerous lines of evidence implicate a role for myeloperoxidase (MPO) in the pathogenesis of atherosclerosis. Enriched within vulnerable plaque, MPO serves as an enzymatic source of eicosanoids and bioactive lipids and generates atherogenic forms of both low- and high-density lipoproteins. These factors likely contribute to clinical studies demonstrating that increased systemic levels of MPO an...

The ability of the neutrophil myeloperoxidase-hydrogen peroxide-halide system to induce the release of human platelet constituents was examined. Both lytic and nonlytic effects on platelets were assessed by comparison of the simultaneously measured release of a dense-granule marker, [(3)H]serotonin, and a cytoplasmic marker, [(14)C]adenine. Incubation of platelets with H(2)O(2) alone (20 muM H(...