The direct effects of potassium-penicillin-G, kanamycin, streptomycin and chloramphenicol on isometric contraction of isolated rat heart muscle were examined. Potassium-penicillin-G did not depress myocardial contractility but rather increased it. Those increases are not due to penicillin itself but due to a small amount of K+ in potassium-penicillin-G. Kanamycin and streptomycin did show not o...

Three weeks after myocardial infarction in 50 patients the effect of the infusion of a graded dose of dobutamine was compared with that of symptom limited treadmill exercise testing. The following variables were measured: blood pressure, heart rate, ST segment changes, Doppler aortic blood flow, and cross sectional echocardiographic dimensions. The heart rate and double product increased more d...

Cardiovascular complications associated with electroconvulsive therapy (ECT) for depression include dysrythmias, myocardial infarction, cardiac arrest, exaggerated hypertensive responses, and transient myocardial dysfunction.1-3 A variety of ECG changes have been demonstrated to occur in association with ECT and other central nervous system events. Although some studies have suggested that thes...

Acute myocardial infarction causes depression of left ventricular function, but the capacity of the ventricle to recover from such an injury remains unknown. This problem was explored by measuring left ventricular function in eight intact conscious dogs before, 1 hr after, and again 6-8 days after myocardial infarction. Acute myocardial infarction was produced using a technique which entails gr...

Objective: This study aimed to assess the incidence of anxiety and depression among AMI patients during COVID-19 pandemic in Pakistan.
 Material & Method: cross-sectional was conducted from February 27 June 2, 2020, at Cardiology ward Dera Ghazi Khan Teaching Hospital. Total 611 selected through convenience sampling. The were requested respond Hospital Anxiety Depression Scale (HADS) d...

In hypertension, both reduced vascular supply and increased cardiac demand contribute to the development of (silent) myocardial ischemia. Our aim was to determine the prevalence of ST-segment depression and to analyze contributing factors in asymptomatic, previously untreated, older hypertensives. From a population survey, in 184 patients with mild hypertension (4 times systolic blood pressure ...

BACKGROUND Major depressive disorder (MDD) is an independent risk factor for coronary heart disease (CHD), and influences the occurrence and prognosis of cardiovascular events. Although there is evidence that antidepressants may be cardioprotective after acute myocardial infarction (AMI) comorbid with MDD, the operative pathophysiological mechanisms remain unclear. Our aim was therefore to expl...

BACKGROUND The development of ST-segment depression during adenosine myocardial perfusion imaging (MPI) has been shown to be an independent predictor of subsequent cardiac events and worse outcome, particularly in association with ischemic defects. However, the prognostic significance of ST-segment depression with adenosine in patients with normal MPI is not known. METHODS AND RESULTS We perf...

Background: The electrocardiography (ECG) is considered as a fundamental tool in identifying the location and managing the symptoms of acute myocardial infarction. The aim of the present study is to study different ECG patterns according to the vessel involved and then it is correlated with the angiographic findings. Methods: It is a prospective and observational study conducted on 50 patients ...