Ventricular arrhythmias are closely associated with myocardial ischemia and its sequelae. Acute ischemia frequently leads to ventricular fibrillation (Vfib) and to sudden cardiac death. As well, chronic ischemia, if presented as ischemic cardiomyopathy with restricted left ventricular function, is prone to the risk of Vfib. In contrast, scar formation after myocardial infarction leads to reentr...

Background We evaluated whether quantitative circumferential strain (C-strain) analysis using adenosine triphosphate (ATP)stress/rest 3-Tesla (3-T) tagged magnetic resonance (MR) can depict myocardial ischemia as contractile dysfunction on stress. We evaluated whether it can differentiate nonischemia, myocardial ischemia and infarction. We assessed its diagnostic performance in comparison with ...

The incidence of ischemic heart disease (IHD) is increasing worldwide. number patients with IHD or without interventions coming for non-cardiac surgical procedures are increasing. These have an increased risk myocardial ischemia, infarction (MI), conduction disturbances, morbidity, and mortality during the peri-operative period.

To establish an HPLC method for determination of tanshinone IIA in Salvia miltiorrhiza Bunge extract, and observe the protective effect of Salvia miltiorrhiza extract on myocardial ischemia-reperfusion injury in rats. Column used is a Diamonsil C18, mobile phase is methanol-water (75:25), and detection wavelength is 270 nm. Ischemia-reperfusion injury model is replicated, and the size of myocar...

OBJECTIVES The aim of this study was to investigate the effect of granulocyte colony-stimulating factor (G-CSF) on chronic myocardial ischemia in swine. BACKGROUND We recently have reported that G-CSF prevents cardiac remodeling and dysfunction after acute myocardial infarction in mice and swine. It remains unclear whether G-CSF has beneficial effects on chronic myocardial ischemia. METHODS...

OBJECTIVES This study examined the changes in myocardial energy metabolism during myocardial ischemia after "remote preconditioning" and investigated the involvement of adenosine receptors in the mechanisms of this effect. BACKGROUND Recent studies have indicated that a brief period of ischemia and reperfusion (ischemic preconditioning, PC) in a remote organ reduces myocardial infarct size (I...

Myocardial ischemia, while causing cardiomyocyte injury, can activate innate protective processes, enhancing myocardial tolerance to ischemia. Such processes are present in not only the heart, but also remote organs. In this investigation, we demonstrated a cardioprotective process involving FGF21 from the liver and adipose tissue. In response to myocardial ischemia/reperfusion injury in the mo...

Production of proinflammatory cytokines contributes to cardiac dysfunction during ischemia-reperfusion. The principal mechanism responsible for the induction of this innate stress response during periods of myocardial ischemia-reperfusion remains unknown. Toll-like receptor 2 (TLR2) is a highly conserved pattern recognition receptor that has been implicated in the innate immune response to a va...

Summary Acute aortic dissection is an extremely serious condition with a high mortality risk. Symptoms may mimic other emergencies such as myocardial ischemia, often leading to misdiagnosis. A combination between coronary hypoperfusion and relatively rare, but when present it could be fatal. Early diagnosis correct surgical approach are essential success in those patients the rate requires impr...

The biochemical marker of myocardial ischemia is detected prior to the development of myocardial necrosis, i.e. a novel biochemical evaluation based on human serum albumin binding to cobalt, a transitional metal. The evaluation is known as Albumin Cobalt Binding (ACB) Test. ACB Test is applied to detect the presence of Ischemia Modified Albumin (IMA), an albumin which has altered binding capaci...