Although there are mammalian myoblast cell lines, no fish myoblast cell line has been developed so far. The aim of this study was to develop a culture system of muscle explants for fish, as explants provide an approximation of the in vivo conditions for cell proliferation and differentiation, and enable a close comparison with events in muscle regenerating in vivo. Here we describe the main fea...

Abstract Myostatin, a member of the transforming growth factor-? superfamily, is an attractive target for muscle disease therapy because its role as negative regulator and strength. Here, we describe novel antibody therapeutic approach that maximizes potential myostatin-targeted therapy. We generated antibody, GYM329, specifically binds latent form myostatin inhibits activation. Additionally, v...

BACKGROUND A single nucleotide polymorphism (SNP) in the first intron of the myostatin gene (MSTN) is associated with aptness of elite Thoroughbreds to race over sprint, middle or long distances. This intronic marker (g.66493737 T ≻ C), a short interspersed nuclear element (SINE) of 227 bp (Ins227bp) insertion polymorphism in the MSTN promoter, and the adjacent SNP BIEC2-417495 have not been st...

Myostatin, a negative regulator of skeletal muscle growth, is produced from myostatin precursor by multiple steps of proteolytic processing. After cleavage by a furin-type protease, the propeptide and growth factor domains remain associated, forming a noncovalent complex, the latent myostatin complex. Mature myostatin is liberated from latent myostatin by bone morphogenetic protein 1/tolloid pr...

myostatin is a growth factor belonging to the tgfß superfamily. tgfß growth factors are active in the regulation of embryonic development and in tissue homeostasis in adults. myostatin is a growth factor controlling proliferation of myoblasts in embryonic development. mutations in coding sequences of the bovine myostatin (gdf8) gene lead to muscle hyperplasia suggesting its inhibitory function ...


 Background: Hyperglycaemia induces dysregulations in skeletal muscle mass and function. Myostatin (Mstn) follistatin (Fs) are two key regulators of mass, which known to be dysregulated people with hyperglycaemia. Exercise is frequently prescribed counteract these changes; however, the influence exercise intensity unknown. The purpose this study was compare training programs, moderate-int...