Tonkonogi, M., and K. Sahlin. Actively phosphorylating mitochondria are more resistant to lactic acidosis than inactive mitochondria. Am. J. Physiol. 277 (Cell Physiol. 46): C288–C293, 1999.—Oxidative phosphorylation of isolated rat skeletal muscle mitochondria after exposure to lactic acidosis in either phosphorylating or nonphosphorylating states has been evaluated. Mitochondrial respiration ...

Manfridi, Alfredo, Dario Brambilla, and Mauro Mancia. Stimulation of NMDA and AMPA receptors in the rat nucleus basalis of Meynert affects sleep. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1488–R1492, 1999.—The nucleus basalis of Meynert (NBM), a heterogeneous area in the basal forebrain involved in the modulation of sleep and wakefulness, is rich in glutamate receptors, a...

Prinz, Christian, Robert Zanner, Markus Gerhard, Sabine Mahr, Nina Neumayer, Barbara Höhne-Zell, and Manfred Gratzl. The mechanism of histamine secretion from gastric enterochromaffin-like cells. Am. J. Physiol. 277 (Cell Physiol. 46): C845–C855, 1999.— Enterochromaffin-like (ECL) cells play a pivotal role in the peripheral regulation of gastric acid secretion as they respond to the functionall...

Ahrén, Bo, and Peter J. Havel. Leptin inhibits insulin secretion induced by cellular cAMP in a pancreatic B cell line (INS-1 cells). Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R959–R966, 1999.—The effect of leptin on insulin secretion is controversial due to conflicting results in the literature. In the present study, we incubated insulinproducing rat insulinoma INS-1 cells...

Dodd, J. S., J. A. Raleigh, and T. S. Gross. Osteocyte hypoxia: a novel mechanotransduction pathway. Am. J. Physiol. 277 (Cell Physiol. 46): C598–C602, 1999.—Bone is a unique tissue in which to examine mechanotransduction due to its essential role in weight bearing. Within bone, the osteocyte is an ideal cellular mechanotransducer candidate. Because osteocytes reside distant from the blood supp...

RAGAVENDRA R. BALIGA,1 DAVID R. PIMENTAL,1 YOU-YANG ZHAO,2 WILLIAM W. SIMMONS,1 MARK A. MARCHIONNI,3 DOUGLAS B. SAWYER,1 AND RALPH A. KELLY1 1Cardiovascular Division, Brigham and Women’s Hospital and Harvard Medical School, Boston 02115; 3Cambridge Neurosciences, Cambridge, Massachusetts 02139; and 2Department of Medicine, University of California at San Diego School of Medicine, La Jolla, Cali...

DOUGLAS R. SEALS, EDITH T. STEVENSON, PAMELA P. JONES, CHRISTOPHER A. DESOUZA, AND HIROFUMI TANAKA (With the Technical Assistance of Cyndi Long and Mary Jo Reiling) Human Cardiovascular Research Laboratory, Center for Physical Activity, Disease Prevention, and Aging, Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309, and Department of Medicine, Divisions of...

PATRICK PAYAN, ANAICK EDEYER, HÉLÈNE DE PONTUAL, GIL BORELLI, GILLES BOEUF, AND NICOLE MAYER-GOSTAN Laboratoire de Physiologie et Toxicologie Environnementales, EA 2138; Laboratoire de Physiologie Cellulaire et Moléculaire, Centre National de la Recherche Scientifique, UMR 6548; Université de Nice-Sophia Antipolis, Faculté des Sciences, 06108 Nice Cedex; and Laboratoire de Sclérochronologie des...

Sakai, Hiroshi, Fumitaka Ikomi, and Toshio Ohhashi. Effects of endothelin on spontaneous contractions in lymph vessels. Am. J. Physiol. 277 (Heart Circ. Physiol. 46): H459–H466, 1999.—A mode of action of endothelin (ET) on spontaneous contractions was investigated in ring preparations of isolated bovine mesenteric lymphatics. ET-1 at concentrations between 10210 and 1029 M caused a dose-depende...

Wang, Jinjuan, and James C. Rose. Developmental changes in renal renin mRNA half-life and responses to stimulation in fetal lambs. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1130–R1135, 1999.—In the perinatal period there is increased renin gene expression in the kidney compared with other stages of development. This may be related to changes in responsiveness of the renin...