Gastric lactobezoars (GLBs) are the most common form of bezoars in neonates and consist of aggregations of undigested milk constituents. GLB can present with a variety of intra-abdominal clinical symptoms, and occasionally, extra-abdominal symptoms. Conservative management, with a period of bowel rest and intravenous fluids, is the most common treatment regimen for uncomplicated GLB. Surgical m...

Airway mucus hypersecretion and increased oxidative stress are clinical and pathophysiological features of asthma exacerbation. We studied effects of N-acetylcysteine (NAC) as a mucolytic and antioxidant agent in asthma exacerbation. In this randomized, single-blinded, placebo-controlled study 50 patients ( 17 male, 33 female, mean age 48.94+/-13.68) with asthma exacerbation were randomized to ...

BACKGROUND Glutathione (GSH) deficiency is common in HIV-infected individuals and is associated with impaired T cell function and impaired survival. N-acetylcysteine (NAC) is used to replenish GSH that has been depleted by acetaminophen overdose. Studies here test oral administration of NAC for safe and effective GSH replenishment in HIV infection. DESIGN Oral NAC administration in a randomiz...

N-acetylcysteine (NAC), a glutathione precursor and glutamate modulator, has been shown to possess various clinically relevant psychopharmacological properties. Considering the role of glutamate and oxidative stress in depressive states, the poor effectiveness of antidepressant drugs (ADs) and the benefits of drug combination for treating depression, the aim of this study was to explore the pos...

Accessible online at: www.karger.com/journals/res Pela et al. [1] wrote an interesting article recommending daily oral N-acetylcysteine (NAC) as a preventive therapy for patients with chronic obstructive pulmonary disease (COPD). For three reasons, however, I do not share their enthusiasm for this therapy. First, support for the initial premise, namely that NAC may have a beneficial effect on C...

OBJECTIVES We sought to evaluate the cardiac and renal effects of an N-acetylcysteine (NAC)-enhanced intracoronary radiographic contrast agent. BACKGROUND Recent studies suggest that high-dose NAC provides better protection from contrast-induced nephropathy, and the antioxidant properties of NAC may also provide cardiac protection. The use of angiographic contrast agents as a drug delivery ve...

Lung cancer arises as a focal transformation of chronically injured epithelium with cigarette smoke as one of its well recognized causes. Apart from oxidants, cigarette smoke contains several precarcinogens, and it is surprising that not every heavy smoker becomes a victim of malignant disease. This points to the interindividual variability in susceptibility to carcinogens and there are several...

N-acetylcysteine (NAC) a derivative of amino acid L-cysteine is currently used mainly as an antioxidant. Sulfhydryl group (–SH) within its molecule makes possible to directly scavenge reactive oxygen species (ROS). Indirect antioxidant action of NAC rely on augmentation of the level of reduced glutathione (GSH) – a major body’s antioxidant. Since oxidative stress takes a part in pathogenesis of...

Evidence suggests that abnormalities in the corticostriato-thalamic-cortical circuits are one of the key factors underlying the pathophysiology of OCDR, including trichotillomania. Particularly, orbitofrontal cortex, anterior cingulate and ventromedial striatum hypermetabolism has been linked to OCD (Ahmari et al., 2013). Glutamate is the primary neurotransmitter within the cortico-striatothala...

hiele et al. (1) report a study dealing with the impact of -acetylcysteine (NAC) administered simultaneously on preventng iodinated contrast agent-induced nephropathy and reperfusion njury in patients with ST-segment elevation myocardial infarction reated by percutaneous coronary intervention (PCI). The study ncluded 126 patients compared with a placebo-treated group. heir results as well as co...