Title of Document: CIRCUIT ANALYSIS OF SYNAPTIC DYSFUNCTIONS IN THE CA3 AREA OF BACE1 KNOCKOUT MICE Hui Wang, Ph.D, 2012 Directed By: Professor Elizabeth Quinlan Department of Biology / NACS University of Maryland Beta-amyloid precursor protein cleavaging enzyme 1 (BACE1), a major neuronal βsecretase critical for the formation of β-amyloid (Aβ) peptide, is thought to be one of the key therapeut...

The Claisen rearrangements of chorismate (CHOR) in water and at the active site of E. coli chorismate mutase (EcCM) have been compared. From a total of 33 ns molecular dynamics simulation of chorismate in water solvent, seven diaxial conformers I-VII were identified. Most of the time (approximately 99%), the side chain carboxylate of the chorismate is positioned away from the ring due to the el...

Nascent Polypeptide-associated Complex (NAC) was identified in eukaryotes as the first cytosolic factor which contacts the nascent polypeptide chain emerging from the ribosome. NAC is present as a homodimer in Archaea and as a highly conserved heterodimer in eukaryotes. Mutations in NAC cause severe embryonically lethal phenotypes in mice, D. melanogaster and C. elegans. In the yeast Saccharomy...

Multimodal documents combining language and graphs are wide-spread in print media as well as in electronic media. One of the most important tasks to be solved in comprehending graph-text combinations is construction of causal chains among the meaning entities provided by modalities. In this study we focus on the role of annotation position and shape of graph lines in simple line graphs on causa...

We present the EMF Model Transformation framework (EMT), which supports the rule-based modification of EMF models. Model transformation rules are defined graphically and compiled into Java code to be used in model transformation applications. Introduction. The Eclipse Modeling Framework (EMF)[1] provides a modeling and code generation framework for Eclipse applications based on structured data ...

Title of dissertation: QUANTUM COHERENT PHENOMENA IN SUPERCONDUCTING CIRCUITS AND ULTRACOLD ATOMS Kaushik Mitra, Doctor of Philosophy, 2010 Dissertation directed by: Professor Christopher Lobb Department of Physics This thesis consists of theoretical studies of superconducting qubits, and trapped bosons and fermions at ultracold temperature. In superconducting qubits I analyze the resonant prop...

class AbstractPlayer { protected ContentSource source; private Description preferences; private Environment env; protected abstract ContentSource findSource(); protected abstract void setEnvironment(); protected void playContent() { source = findSource(); Content toPlay = source.provideContent(this); setEnvironment(); toPlay.play(env); } Description getPreferences() { return preferences; } void...

Protein kinases play key roles in the induction by human interferon a (IFN-a) of specific gene expression and biological activity in various human cell lines. We now report that IFN-a increased the 7-kb transcript for the E isotype of protein kinase C (PKC-e) and the cellular content ofPKC-e 24 and 48 hr after IFN-a addition (a 2-fold and 6-fold increase, respectively). Furthermore, IFN-a marke...

The purpose of this work was to analyse at the molecular level the DNA recognized by the antibodies to Z-DNA in in situ experiments. Antibodies to Z-DNA interact strongly with R-band positive heterochromatic segments of fixed metaphase chromosomes of Cebus (Viegas-Pequignot et al., 1983). These segments are constituted of a satellite DNA the repeat unit of which is about 1520 base pairs long. T...

ion is an essential ingredient in nearly all methods for system analysis and verification and as such there is a vast body of work describing the use of abstractions in different domains. In this section we give a (non-exhaustive) discussion on related work that involves state space traversal and graphs. In [11], Holte et al. tackle the area of problem solving in artificial intelligence, which ...