The present study was to formulate a transungual drug delivery formulation. We targeted to formulate and evaluate fluconazole film for the nail fungal infection using extracted natural and evaluated penetration enhancer (PE). Model drug fluconazole was formulated with the natural extracted penetration enhancer with different ratios. The solvent for PE extraction was methanol and that extracts w...

A 25-year-old construction worker was installing a window from the inside but bent his upper body to the outside through the window. As he used a nail gun to secure parts to the window sill, the nail gun ricocheted and misfired a nail into his left chest. After evaluation at a peripheral hospital, he was quickly transferred to our tertiary care centre. On initial evaluation he was awake and ale...

BACKGROUND Treatment options for nonunion of the femoral shaft fracture after intramedullary nail fixation are controversial. The methods of exchanging an existing nail with a larger-sized nail, dynamization, removal of the nail followed by plating, and bone grafting have all been reported. From those options, exchange nailing seems to be the most popular choice. In our study, we used plate aug...

This study designs and evaluates a new nail clipper for the elderly using ergonomic methods. The nail clipper usage problems and requirements were collected first. After requirement analysis we applied ergonomic simulation in redesigning the nail clipper and developing a pedal plate. A usability test was conducted to evaluate both typical and newly developed nail clippers using 20 elder partici...

OBJECTIVE To assess glycation of nail proteins as a tool in the diagnosis of diabetes. METHODS Glycation of nail proteins was assessed using a modified photometric nitroblue tetrazolium-based assay, which provides information about average glucose values of the last 6-9 months. Analysis is possible on 10 mg of nail clippings with a within-run coefficient of variation (CV) of 11%. The analyte ...

Peri-implant fractures distal to an antegrade femoral nail are uncommon injuries, with no current consensus on the best treatment modality. We are presenting three cases of periimplant fractures distal to an antegrade femoral nail. All patients sustained an initial traumatic injury, which was managed with an antegrade femoral nail fixation. They subsequently suffer a second injury which causes ...

Weir Mitchell (1872) and Sharpey-Schafer (1931) reported that section of a nerve supplying cutaneous fibres to the fingers results in a retardation of nail growth. Head and Sherren (1905), however, believed that the slowing of growth observed in these cases wvas due entirely to the immobilization of the limb either as a result of splinting or paralysis and that division of sensory fibres withou...

background:   although intramedullary nailing (imn) is an established and accepted operative treatment for femoral shaft fracture in patients younger than 60, there is a lack of data on the results of this treatment on those over 60. the purpose of this study was to determine if the outcome of imn for femoral shaft fracture in elderly patients is also acceptable. particular challenges in this g...

BACKGROUND Nail psoriasis occurs in up to 50% of patients affected by psoriasis, with a significant impact on quality of life that leads to a real clinical need for new therapeutic options. AIM To confirm whether the strengthening and hardening properties of the hydroxypropyl-chitosan (HPCH) nail lacquer could improve the structure of the nail plates on psoriatic nails. MATERIALS AND METHOD...

Noninvasive techniques for nail imaging would be useful for confirming diagnosis and monitoring treatment response at the microscopic level in patients with nail psoriasis. However, the use of ultrasound and high-resolution magnetic resonance imaging in nail evaluation is limited. Optical coherence tomography (OCT) produces high-resolution images of transversal tissue sections and represents an...