نتایج جستجو برای: nano drug

تعداد نتایج: 637211  

Journal: :Catalysts 2023

A biocatalyst is an enzyme that speeds up or slows down the rate at which a chemical reaction occurs and certain processes by 108 times. It used as anticancer agent because it targets drug activation inside tumor microenvironment while limiting damage to healthy cells. Biocatalysts have been for synthesis of different heterocyclic compounds also in nano delivery systems. The use nano-biocatalys...

Journal: :Characterization and application of nanomaterials 2022

In the last several decades, cardiovascular diseases (CVDs) have emerged as a major hazard to human life and health. Conventional formulations for treatment of CVD are available, but they far from ideal because poor water solubility, limited biological activity, non-targeting, drug resistance. With advancement nanotechnology, novel delivery approach CVDs has emerged: nano-drug systems (NDDSs). ...

Journal: :Physical Chemistry Chemical Physics 2023

Release of drug or vaccine molecules from macro-, micro-, and nano-sized carriers is usually considered to be limited by diffusion and/or carrier dissolution erosion. The corresponding experimentally observed kinetics...

2014
Elham Asadpour Hamid Reza Sadeghnia Ahmad Ghorbani Mohammad Taher Boroushaki

Today, special attention is paid to the use of zirconium dioxide nanoparticle (nano-ZrO2), a neutral bioceramic metal, particularly for drug and gene delivery in medicine. However, there are some reports implying that use of nano-ZrO2 is associated with cytotoxic effects like inhibiting the cell proliferation, DNA damage and apoptosis. In the present study, we examined whether nano-ZrO2 alters ...

2017
WG Singleton AM Collins AS Bienemann CL Killick-Cole HR Haynes DJ Asby CP Butts MJ Wyatt NU Barua SS Gill

BACKGROUND The pan-histone deacetylase inhibitor panobinostat is a potential therapy for malignant glioma, but it is water insoluble and does not cross the blood-brain barrier when administered systemically. In this article, we describe the in vitro and in vivo efficacy of a novel water-soluble nano-micellar formulation of panobinostat designed for administration by convection enhanced delivery...

2016
Rahul Jadia Cody Scandore Prakash Rai

Cancer continues to remains a major healthcare problem across the world despite strong translational research efforts towards tackling the disease. Surgery, when possible, along with radiation and chemotherapy continue to remain the mainstay of cancer treatment. Novel targeted therapies or biologics and immunotherapies have recently been approved to improve treatment efficacies while reducing c...

2014
Devasier Bennet Se Chan Kang Jongback Gang Sanghyo Kim

Plants contain enriched bioactive molecules that can protect against skin diseases. Bioactive molecules become unstable and ineffective due to unfavorable conditions. In the present study, to improve the therapeutic efficacy of phytodrugs and enhance photoprotective capability, we used poly(D,L-lactide-co-glycolide) as a carrier of apple peel ethanolic extract (APETE) on permeation-enhanced nan...

Journal: :European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 2009
Sungwon Kim Jong-Ho Kim Oju Jeon Ick Chan Kwon Kinam Park

Engineered polymers have been utilized for developing advanced drug delivery systems. The development of such polymers has caused advances in polymer chemistry, which, in turn, has resulted in smart polymers that can respond to changes in environmental condition such as temperature, pH, and biomolecules. The responses vary widely from swelling/deswelling to degradation. Drug-polymer conjugates ...

2011
Upendhar Gandapu R. K. Chaitanya Golla Kishore Raju C. Reddy Anand K. Kondapi

BACKGROUND Curcumin (diferuloylmethane) shows significant activity across a wide spectrum of conditions, but its usefulness is rather limited because of its low bioavailability. Use of nanoparticle formulations to enhance curcumin bioavailability is an emerging area of research. METHODOLOGY/PRINCIPAL FINDINGS In the present study, curcumin-loaded apotransferrin nanoparticles (nano-curcumin) p...

2017
Christina M. Pickering Connor S. Dobson Peter R. Panizzi Allan E. David Robert D. Arnold

Liposomal drug carriers are nano-scale, spherical particles with a phospholipid bilayer surrounding an aqueous core and are commonly used for chemotherapeutic delivery. Chemotherapy efficacy is limited by toxicity and tumor drug resistance; however, with increased circulation and improved tumor deposition due to the enhanced permeability and retention effect, liposomes increase treatment effica...

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