The aim of the present investigation was to compare the efficacy and tolerability of azelastine (CAS 58581-89-8) (1.12 mg/day) and levocabastine (CAS 79547-78-7) (0.4 mg/day) nasal spray administered twice daily to patients with seasonal allergic rhinitis. A total of 180 patients participated in a 4-week, double-blind, parallel group (n = 90 each) study. Symptom severity of nasal, ocular and ot...

OBJECTIVE To understand the mechanism underlying the nasal congestive response to irritant challenge. METHODS We exposed 22 subjects--8 with seasonal allergic rhinitis (SAR), 6 with perennial allergic rhinitis (PAR), and 8 normals--to chlorine (Cl2) gas (1.0 ppm x 15 min.) by nasal CPAP mask. Control exposures (filtered air) were carried out on separate days, with counter-balancing of exposur...

Iota-carrageenan is a sulfated polysaccharide extracted from red seaweeds, which, formulated into nasal spray, has already been proven safe and effective in viral upper respiratory infections. In Calu-3, human epithelium cell line, we explored the activity of formula iota-carrageenan sodium chloride against SARS-CoV-2. this study, assayed formula, approved as spray for use, effectively inhibite...

Topical drug delivery to poorly ventilated paranasal sinuses is challenging. Pulsating aerosols can improve the deposition of drugs like cortisol in sinuses. The current study compares effect Budesonid administered as pulsating aerosol comparison conventional nasal spray

The effect of pre-harvest sprays of chitosan on post-harvest decay and quality of strawberries stored at 3 and 13°C was investigated. Strawberry plants were sprayed with 2, 4 and 6 g l, chitosan solutions as the fruit were turning red. A second spray was performed after 10 days. Fruit were picked 5 and 10 days after each spray. Harvested fruit from chitosan sprayed plants were challenged with B...