BACKGROUND The hypothalamic neuropeptide arginine vasopressin is thought to play an important role in the pathophysiology of affective disorders and the hyperactivity of the hypothalamic-pituitary-adrenocortical system that frequently accompanies them. Postmortem studies as well as clinical investigations have described elevated levels of vasopressin in the brain and plasma of depressed patient...

Proximal duodenal bicarbonate secretion is an important factor in humans and animals protecting the mucosa against acid-peptic damage. This study examined the mechanisms responsible for the central nervous system regulation of duodenal bicarbonate secretion by calcitonin gene-related peptide (CGRP) in unrestrained rats. Cerebroventricular administration of rat CGRP significantly inhibited basal...

Normal aging is associated with vasopressin neuron adaptation, but little is known about its effects on the release of apelin, an aquaretic peptide colocalized with vasopressin. We found that plasma vasopressin concentrations were higher and plasma apelin concentrations lower in aged rats than in younger adults. The response of AVP/apelin neurons to osmotic challenge was impaired in aged rats. ...

Arginine vasopressin is elevated in congestive heart failure. To determine the effect of arginine vasopressin upon systemic hemodynamics and regional blood flows, we administered the specific inhibitor of the vascular action of vasopressin [1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid),2-(O-methyl)-tyrosine]-arginine vasopressin [d(CH2)5Tyr(Me)AVP] to 15 dogs with chronic right-...

the objective of this study was to investigate the effect of intranasal phototherapy on nasal microbial flora in patients with allergic rhinitis. this prospective, self-comparised, single blind study was performed on patients with a history of at least two years of moderate-to-severe perennial allergic rhinitis that was not controlled  by  anti-allergic drugs.  thirty-one  perennial  allergic r...

Crit Care Resuscitation ISSN: 1441-2772 4 September 2006 8 3 239-240 © C r i t C a r e R es u s c i t a t i on 20 06 www.jficm.anzca.edu.au/aaccm/journal/publications.htm Points of view retic hormone, and is deficient in patients w shock. It is therefore being increasingly consid alternative or additional vasopressor therapy patients. Small cases series and a small pha suggest it as clinical be...

VASOPRESSIN ANATOMY OF THE MOUSE BRAIN FEBRUARY 2010 BENJAMIN D. ROOD, B.S., BATES COLLEGE M.S., UNIVERSITY OF MASSACHUSETTS AMHERST Ph.D., UNIVERSITY OF MASSACHUSETTS AMHERST Directed by: Geert J. de Vries The nine amino acid peptide vasopressin acts as a neurohormone in the periphery and a neurotransmitter / neuromodulator in the central nervous system. Historically, research on vasopressin n...

A plasma membrane fraction was prepared from pig kidney medulla. It contained lysine-vasopressin-sensitive adenylate cyclase activity (maximum activation: 4to 6fold, apparent Km value for the hormone: about 5 X 1OV M). Lysine-vasopressin was not inactivated by the membrane preparation even at low hormonal concentrations. The specific [3H]lysine-vasopressin (vasopressin) binding sites found are ...

Alzheimer's disease (AD) is the most common form of dementia in the elderly. For more effective therapy early diagnostic markers could be beneficial. Therefore we compared one year old rats with adults and examined if changes in possible brain markers of AD preceeded memory decline. We also tested if vasopressin-deficient animals were useful model of AD as vasopressin has well known positive ef...

In this study, cells derived from rat inner medullary collecting duct formed a polarized monolayer when grown in wells on a membrane. When the membrane was sealed in an Ussing apparatus, the cells passed water from their apical to basolateral surfaces in the presence of an osmotic gradient. This was detected by the movement of the meniscus (1 mm = 1 microL) in a capillary tube connected to the ...