BACKGROUND & OBJECTIVES Haemophilus influenzae is an important cause of mortality and morbidity among young children in developing countries. Increasing incidence of antibiotic resistance especially production of extended spectrum beta lactamase (ESBL) has made treatment and management of H. influenzae infection more difficult. Nasopharyngeal H. influenzae isolates are excellent surrogate for d...

Nasopharyngeal carcinoma is an uncommon head and neck malignancy which can rarely present with cranial nerve palsies. Here we report a case of nasopharyngeal mass presented initially ophthalmic complaints due to compression nerves in superior orbital fissure resulting Rochen-Duvigneaud syndrome. It was histologically proven as non keratinising differentiated type

The epidemiology of Epstein-Barr virus (EBV) infection in populat ions at dif ferent risk for EBV-associated diseases indicates signif icant differences between the populat ions. EBV infection takes place much earlier in Uganda, where all chi ldren are infected before the age of 2 to 3 years, than in Southeast Asia, where nasopharyngeal carcinoma is prevalent. It is proposed that such early inf...

no nasopharyngeal tumor was identified in 12 cases with adult OME that were reviewed.[8] Postnasal space examination is further necessitated by the fact that nasopharyngeal tumor is common in the third and fifth decades of life, at which stage most of our patients were. Nasopharyngeal tumors have been known to present with otological features of OME, in addition to nasal, neuro-ophthalmic and n...

BACKGROUND While almost all infants are infected with respiratory syncytial virus (RSV) before the age of 2 years, only a small percentage develops severe disease. Previous studies suggest that the nasopharyngeal microbiome affects disease development. We therefore studied the effect of the nasopharyngeal microbiome on viral load and mucosal cytokine responses, two important factors influencing...

TFAP2A is a transcription factor that orchestrates a variety of cell processes, including cell growth and tissue differentiation. However, the regulation of TFAP2A in human nasopharyngeal carcinoma tumorigenesis and its precise mechanism of action remain largely unknown. In this study, we investigated the biologic role and clinical significance of TFAP2A in nasopharyngeal carcinoma growth and p...

PCR was used to detect Haemophilus influenzae in samples of nasopharyngeal secretion and middle ear effusion (MEE). Nasopharyngeal secretions were collected from 102 patients with otitis media with effusion and from 111 healthy subjects. Eighty samples of MEE were collected from patients with otitis media with effusion. A pair of primers was designed to amplify a DNA segment of the gene encodin...

The aim of the study was to investigate the miR-10b regulatory mechanism for epithelial-mesenchymal transition (EMT) and its effect on the proliferation and migration of nasopharyngeal carcinoma cells. RT-qPCR was used to detect the expression of miR-10b in CNE1 nasopharyngeal carcinoma cell line. The NP69 nasopharyngeal mucosal cell line was used to determine the expression of miR-10b after in...

BACKGROUND Cigarette smoking is associated with the etiology of nasopharyngeal carcinoma; however, the influence of smoking on survival in patients with established nasopharyngeal carcinoma remains unknown. METHODS We retrospectively analyzed 1,849 patients with nasopharyngeal carcinoma who were categorized as never, former, and current smokers. Cumulative effect of smoking was defined in ter...