In present study possible ameliorative efficacy of aqueous extract of bark of Alstonia scholaris (ASE) in cultured human lymphocytes against Bleomycin-induced cytogenetic alterations has been reported. Cultures were treated either alone with Alstonia scholaris aqueous bark extract (50μg/ml) or in combination with radiomimetic drug Bleomycin (15μg/ml). Positive implications about radioprotective...

The administration of 5-azacytidine to mice (AKR strain) prior to irradiation with a supralethal dose of X-rays markedly reduces their mortality. In the pretreated animals the number of blood leukocytes and of bone marrow nucleated cells is considerably higher than in the animals that have been only irradiated. It is supposed that the radioprotective effect of 5-azacytidine favourably in­ fluen...

Mechanism of radioprotective action of caffeine by studying the gamma radiation -induced killing of yeast, S. cerevisae is reported. The results reveal that caffeine specifically protects aerobically (oxic) grown cells from gamma - radiation and sensitizes anaerobically (hypoxic) grown cells to some extent. Using radiation sensitive strains which lack recombinational pathway, it was found that ...