Transcription activator-like effectors (TALEs) are DNA-related proteins that recognise and bind specific target sequences to manipulate gene expression. Recently determined crystal structures show that their common architecture reveals a superhelical overall structure that may undergo drastic conformational changes. To establish a link between structure and dynamics in TALE proteins we have emp...

Under 5 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 62 8.1 5 to 9 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 42 5.5 10 to 14 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 46 6.0 15 to 19 years . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 8.0 20 to 24 years . . . . . . . . . . . . . . . . . . . . . . ....

Crittenden Springs in northeastern Nevada yields M. gracilitatis Zone ammonoids renowned for the finely detailed, exquisite preservation of the test, which sometimes even displays relict color patterns. Evidence reveals most of the fossiliferous Lower Triassic beds in the Crittenden Springs area are overturned and this conclusion places the Meekoceras gracilitatis Zone portion of the section an...

There are approximately 470,000 km(2) of karst aquifers that feed many large springs in North China. Turbulent flow often exists in these karst aquifers, which means that the classical ground water model based on Darcy's law cannot be applied here. Ground water data are rare for these aquifers. As a consequence, it is difficult to quantitatively investigate ground water flow in these karst syst...

Correct reproductive timing is crucial for fitness. Breeding phenology even in similar species can differ due to different selective pressures on the timing of reproduction. These selection pressures define species' responses to warming springs. The temporal match-mismatch hypothesis suggests that timing of breeding in animals is selected to match with food availability (synchrony). Alternative...

In recent years there have been many advances in the miniaturization of electronic and mechanical technologies for space applications. However, the satellite power requirement does not reduce linearly with the satellite mass, creating the need for small satellite deployable arrays. This paper outlines the current state of technology for small satellite deployable structures, briefly discussing ...

It is essential to understand sediment and nutrient sources and their spatial and temporal patterns to design effective mitigation strategies. However, long-term data sets to determine sediment and nutrient loadings are scarce and expensive to collect. The goal of this study was to determine seasonal patterns of suspended sediment (SS), total N (TN), and total P (TP) concentrations and loadings...

A study of the large, deep-seated Rosone landslide (Italian Western Alps) is presented. A large amount of geological and geomechanical data has been collected in this area, due to the presence of various villages and man-made structures, and an automatic monitoring system was installed in December 2000. Since its installation, this system has been showing a continuous slow movement with periodi...

A three-dimensional analytical model of the knee-joint is presented, taking into account the geometry of the joint surfaces as well as the geometry and material properties of the ligaments and capsule. The position of a large number of points on the joint surfaces is measured and the geometry of these surfaces is then approximated by polynomials in space. The ligaments and capsule are represent...