The layout of a factory is essential to costand time-efficient production in today’s competitive manufacturing environment. This thesis provides assistance for the rough factory layout planning process, which is the initial design phase of factory work floors. While currently used pure analog approaches are easy to handle and support collaborative work, they miss the advantages of digital plann...

Unicystic ameloblastoma is a tumor of odontogenic origin. It is not a rare neoplasm and most often the lesion is asympthomatic. However, large lesions may cause painless swelling of the jaws. Here we report a case of unicystic ameloblastoma with pain, swelling of the posterior jaws along with teeth mobility. Samples of incisional biopsy of the lesion and also interaoperative frozen section were...

We applied a learning methodology framework to assist in the threshold-based segmentation of non-small-cell lung cancer (NSCLC) tumours in positron-emission tomography-computed tomography (PET-CT) imaging for use in radiotherapy planning. Gated and standard free-breathing studies of two patients were independently analysed (four studies in total). Each study had a pet-ct and a treatment-plannin...

planning systems (RTPS) is generally used for patient planning only, but it also contains enormous quantities of valuable information regarding patient anatomic geometries, tissue outlining, treatment approaches and dose distribution. Attempts on implementing a Web-based digital archiving system (DAS) in order to provide immediate access to the treatment planning information were described in t...

AIM The aim of the study was to verify the dose distribution optimisation method in pulsed brachytherapy. BACKGROUND The pulsed-dose rate brachytherapy is a very important method of breast tumour treatment using a standard brachytheraphy equipment. The appropriate dose distribution round an implant is an important issue in treatment planning. Advanced computer systems of treatment planning ar...

Introduction: The application of 3D volumetric imaging modalities in treatment planning of radiation therapy can provide more precisely define tumor localization, and computed tomography (CT) is the most common accepted method for treatment planning. Given the lack of a CT scanner stationed in all radiotherapy departments and equipping most of the medical linear accelerators wi...

BACKGROUND Tumor-Treating Fields (TTFields) are a novel treatment strategy for glioblastoma (GBM) that is approved for the use concomitantly to adjuvant chemotherapy. Preclinical data suggest a synergistic interaction of TTFields and radiotherapy (RT). However, the dosimetric uncertainties caused by the highly dense arrays have led to caution of applying the TTF setup during RT. METHODS In a ...

Equivalent dose from neutrons produced during proton radiotherapy increases the predicted risk of radiogenic late effects. However, out-of-field neutron dose is not taken into account by commercial proton radiotherapy treatment planning systems. The purpose of this study was to demonstrate the feasibility of implementing an analytical model to calculate leakage neutron equivalent dose in a trea...