Mills, Paul J., Brian P. Kennedy, Jose S. Loredo, Joel E. Dimsdale, and Michael G. Ziegler. Effects of nasal continuous positive airway pressure and oxygen supplementation on norepinephrine kinetics and cardiovascular responses in obstructive sleep apnea. J Appl Physiol 100: 343–348, 2006; doi:10.1152/japplphysiol.00494.2005.—Obstructive sleep apnea (OSA) is characterized by noradrenergic activ...

BACKGROUND Chronic excessive norepinephrine (NE) causes cardiac sympathetic nerve terminal abnormalities, myocardial beta-adrenergic receptor downregulation, and beta-adrenergic subsensitivity. The present study was carried out to determine whether these changes could be prevented by antioxidants. METHODS AND RESULTS Ferrets were administered either NE (1.33 mg/d) or vehicle by use of subcuta...