Paradoxical effects (bronchoconstriction instead of bronchodilatation) have been reported after inhalation of beta2-mimetics in asthmatic children, and it has been suggested that this was due to osmolality and pH changes of the nebulizer solution. We tested commercially available nebulizer solutions and found osmolality changes after 5, 10 and 15 min of nebulization. Osmolality was measured in ...

BACKGROUND Inhaled recombinant human DNase I (rhDNase) improves clearance of visco-elastic secretions in patients with cystic fibrosis. Because of their portability, newer-generation vibrating-mesh nebulizers offer greater convenience for the patient, but their efficiency in delivering rhDNase has not been determined. METHODS We compared a newer-generation vibrating-mesh nebulizer (Omron Micr...

Vitamin K1 (VK1) is a very lipophilic and photosensitive molecule contained in some vegetables. Recently, the use of VK1 on the skin has been proposed for different pharmaceutical or cosmeceutical applications. In this study, an innovative strategy for the administration of VK1 on the skin was proposed. In particular, to overcome the drawbacks associated with a VK1-containing fatty ointment ava...

OBJECTIVE A foreign body aspiration in the tracheobronchial tree is a dangerous medical condition in the childhood period. Although rigid bronchoscopy is a safe procedure, it may cause complications. The aim of this study was to present our bronchoscopy experience and to evaluate the efficacy of pre-operative administration of nebulized albuterol and budesonide combination for reducing intra-op...

BACKGROUND Olfactory dysfunction is deemed to be a significant contributor to poor quality of life in chronic rhinosinusitis (CRS). OBJECTIVE To assess and to compare the effectiveness of three modalities of corticosteroids administration in patients with CRS. STUDY DESIGN A prospective randomized controlled study METHODS Thirty patients with CRS were randomized in three groups depending ...

Adult patients suffering from acute asthma presenting to the Emergency Department with an FEV1 of less than 40% of predicted were randomized into four treatment groups. They were treated with nebulized albuterol at a high (7.5 mg) or standard (2.5 mg) dose given either continuously through 1 h, or intermittently every hour, for 2 h. When the FEV1 improvements for the different groups at 2 h wer...

A new method of experimental infection of ovine progressive pneumonia virus (OPPV), aerosol nebulization (Nb), was compared to intravenous (IV) and oral (PO) methods of experimental infection. Seven month old lambs were given 3.5 × 10 TCID50 of Dubois OPPV LMH19 isolate using IV, PO, or Nb methods and were monitored for infection using cELISA and OPPV quantitative (q) PCR for 35 weeks. Four out...

To the Editor: In the recent paper by El Taoum and associates,1 an in vitro comparison of aerosol dose delivery using jet and vibrating mesh nebulizers with a variety of nasal interface devices in pediatric patient models was presented. The results of this study demonstrated that the jet nebulizer was more efficient than the vibrating mesh nebulizer across all of the nasal interface devices tes...

The effect of nebulizer solution temperature and dilution air humidity on the size and solute concentration of aqueous aerosol droplets were studied. Four combinations of jet-nebulizers with air compressors or oxygen sources and one ultrasonic nebulizer were tested. The temperature to which the nebulizer solution of each system fell during generation was measured. The nebulizers were then kept ...