Biomarkers proposed in the schizophrenia diathesis have included neurocognitive deficits in domains such as working memory that implicate prefrontal systems. However, the relationship between these biomarkers and psychopathological markers such as schizotypy has not been systematically assessed, particularly in adolescent offspring of schizophrenia patients. Convergence between these markers ma...

BACKGROUND Familial correlations underlie heritability estimates of psychosis. If gene-environment interactions are important, familial correlation will vary as a function of environmental exposure. METHODS Associations between sibling and parental schizotypy (n = 669 pairs, n = 1222 observations), and between sibling schizotypy and patient CAPE psychosis (n = 978 pairs, n = 1723 observations...

Abstract Schizotypy is a personality trait in healthy people that related to schizophrenic symptoms. People with high schizotypy tend have hallucinatory experiences. The relationship between and experiences could be explained by mindfulness traits stress. To test our hypothesized model, we conducted preregistered online survey Japanese non-clinical sample. In the analysis, structural equation m...

This article describes the development of a measure of schizotypic referential thinking. The authors present a 34-item questionnaire that includes a wide variety of referential thoughts and experiences, including both simple and guilty ideas of reference. The Referential Thinking Scale (REF) displays adequate internal consistency and strong relations with other measures of Schizotypy, such as t...

Positive schizotypal traits have been associated with right hemisphere activation. Previous research has indicated that the left and right hemispheres differ in their processing of semantic ambiguity; specifically, given sufficient time, the left hemisphere primes dominant meanings and inhibits subordinate meanings, and the right hemisphere primes both dominant and subordinate meanings. The aut...

Abstract The aim of this study was to better understand the relation schizotypy traits with sensory gating ability in a sample community-dwelling individuals high and low traits. Sensory assessed through paired click paradigm mid-latency evoked responses (i.e., P50, N100, P200), while were SPQ-BR which used classify participants into “high” “low” groups. Based on prior work, we hypothesized tha...

PURPOSE Obsessive-compulsive disorder (OCD) patients exhibit a noninhibition response pattern very similar to that observed in schizotypy patients in cognitive tasks. It has been suggested that the reduced cognitive inhibition observed in both schizotypy and OCD may result in the frequent entry into awareness of unacceptable urges and intrusive thoughts. The aim of this study was to investigate...

Both autism spectrum conditions (ASCs) and schizophrenia spectrum conditions (SSCs) involve altered or impaired social and communicative functioning, but whether these shared features indicate overlapping or different etiological factors is unknown. We outline three hypotheses (overlapping, independent, and diametric) for the possible relationship between ASCs and SSCs, and compare their predic...