The detection of an increase in the frequency of mutants in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene of circulating T-cells has been proposed as a method to evaluate the biological effects of human exposure to environmental mutagens. We exposed adult human T-cells in vitro to 1-nitrosopyrene (1-NOP), a partially reduced metabolite of 1-nitropyrene, a ubiquitous environment...

Ruminantlarda özellikle sığırlarda enterik fermantasyondan kaynaklanan metan (CH4), hem öneli bir sera gazıdır ve de yein brüt enerjisinde %12 kayba neden olur. Bu nedenle, ruminant üretim sisteminde metajenezi azaltmak için uygun maliyetli stratejilere ihtiyaç vardır. Son çalışmalar, kimyasal olarak sentezlenen bileşik 3-Nitrooxypropanol (3-NOP), CH4 üretimini %30'a kadar azaltma potansiyeline...

The aim of this study is to analyse dynamic programming in large scale, complex networks is more important in the fields of scientific and engineering. Recent applications needs the analysis of scale-free networks with many millions of nodes and edges; presenting a huge computational challenge. Employing distributed networks on-chip infrastructure presents a unique opportunity of delivering pow...

In this paper we calculate the exact cumulative distribution function (CDF) of path distance (L1 norm) between a randomly selected intersection and k-th nearest node Cox point process driven by Manhattan Poisson line process. The CDF is expressed as sum over integer partition $p\!\left(k\righ...

The opioid-like receptor (NOP) is widely expressed throughout the human immune system. Here, we report that human peripheral blood lymphocytes (PBLs) express transcripts encoding the NOP receptor agonist, orphanin FQ/nociceptin (OFQ/N). OFQ/N transcripts in resting PBLs were restricted to CD19+B cells and contained a novel 5' exon (ImEx2b), replacing exons 1 and 2 found in neuronal transcripts....

The isolation of an opioid receptor-related clone soon led to the isolation and characterization of a new neuropeptide, termed orphanin FQ or nociceptin (OFQ/N). This heptadecapeptide binds to the NOP(1) (previously termed ORL1) receptor with exceedingly high affinity, but does not interact directly with classical opioid receptors. Functionally, the actions of OFQ/N are diverse and intriguing. ...

Modulatory mechanisms of object-recognition memory in the perirhinal cortex Nicole Gervais, Ph.D. Concordia University, 2014 The present thesis examined whether acetylcholine (ACh) and 17-β estradiol (E2) modulate object-recognition memory (ORM) and perirhinal cortex (PRh) function. ORM was assessed using the Novel-Object Preference (NOP) test or the delayed non-match-to-sample (DNMS) task. The...

Wireless networks offer more flexibility and adapt easily to changes in the configuration of the network. Wireless ad hoc network is a decentralized type of wireless network. Mobile ad hoc network is a type of ad hoc network, in which each and every node can change its location. Frequent link breakages exist due to its high mobility of nodes which leads to frequent path failures and route disco...

Alcohol and nicotine are often co-abused. Although the N/OFQ-NOP receptor system is considered a potential target for development of drug abuse pharmacotherapies, especially for alcoholism, little is known about the role of this system in nicotine dependence. Furthermore, the effect of prior history of nicotine dependence on subsequent nicotine and alcohol taking is understudied. Using an opera...