several other RNA motifs form well-defined complexes with individual aminoglycosides, which makes these antibiotics excellent model ligands for the study of RNA recognition. The target “promiscuity” of the aminoglycosides has been attributed to two major factors: 1) their highly charged nature, which is responsible for their eletrostatically driven RNA-binding mode and 2) their conformational a...

Abstract. Suwito W, Nugroho WS, Wahyuni AETH, Sumiarto B. 2021. Antimicrobial resistance in coagulase-negative staphylococci isolated from subclinical mastitis Ettawa Crossbred goat (PE) Yogyakarta, Indonesia. Biodiversitas 22: 3418-3422. Subclinical (SCM) Goat is most frequently caused by with a significant reduction milk yield. The aim of this study to determine antimicrobial patterns (CoNS) ...

background: one of the most important producers of high quality industrial enzymes is the gram-positive bacterium, bacillus subtilis (b. subtilis). one major limitation that hinders the wide application of b. subtilis is the secretion of high levels of extracellular proteases which degrade the secreted foreign proteins. in this study, homologus recombination technique was used to knock out its ...

background: to determine the efficacy of three different antiseptic solutions (control group (i), antibiotic solution – neomycin and polymyxin (ii), chlorhexidine 0.4% (iii), and povidone – iodine 10% (iv)) in disinfecting contaminated bone fragments. methods: under sterile conditions, the femora of 12 rabbits were removed and cut into six millimeter pieces. a total of 200 bone specimens were o...

Pre-treatment of rice roots for 2 h in aerobic conditions with two phospholipase C (PLC) antagonists, neomycin and compound 48/80 (C48/80), inhibited accumulation of gamma-aminobutyric acid and increased the loss of K+ in the medium during 3 h of anoxia. The presence of Ca2+ and A23187 (Ca2+ ionophore) nullified the effect of PLC inhibitors. Pre-treatment of rice roots with neomycin and C48/80 ...

We demonstrate new method for the synthesis of gold and silver nanoparticles from pineapple extract. Furthermore, we have studied interactions between nanoparticles (gold and silver) with aminoglycosides such as Kanamycin A, Neomycin. Both nanoparticles were prepared by reducing AuCl4 and AgNO3 using pineapple extract, kanamycin A and neomycin as both reducing and stabilizing agents respectivel...

Basal cell carcinoma (BCC) is the most common skin cancer, occurring more frequently than malignancies of any other tissue or organ, either individually or in total. Medical treatment modalities of BCC offer cost reduction and clinical advantages in selected cases. Neomycin has been reported to have an important role on proliferation of endothelial cells and neoplastic cells. This finding may l...