1 DO MECHANICAL AND HUMAN FACTORS COMBINE TO OVERVENTILATE TRANSPORTED INFANTS? A. Leslie (1,2) J. Behrsin (1,2), A. Kage (1,2) Gareth Penman (2) (1) CenTre Neonatal Transport Servic; (2) University Hospitals of Leicester NHS Trust, UK Introduction A recent audit from our service demonstrated hypocarbia (pCO2<4KPa) at the end of transport in 12.5% of ventilated transports1. The Baby-pac ventila...

Fetal growth is determined by many factors. These include genes, maternal nutrient supply, placental transport function, nutrient concentration gradient between maternal and fetal blood, placental blood flow, etc. Among these factors, gene determinants play an important role. Their mutation and expression are related to the perinatal growth phenotype [1-5]. In this review, perinatal growth phen...

abstract background: a newborn is highly fragile whose death can be caused by embryonic, intra partum, and postpartum factors. identifying the causes of death is the first step to be taken in order to decrease the death rate. the present study was aimed at finding out how neonatal factors and therapeutic actions affect death of newborn babies. materials and methods: this is a case-control study...

background : meningitis is more common during the neonatal period than other periods of life and has a prevalence of one in 1000 live births. the similarity of its clinical manifestations with other infectious diseases makes it difficult to diagnose. the aim of the current study was to determine the relationship between age, sex, clinical signs and symptoms and laboratory test results of newbor...

Neonatal heart failure is characterized by many unique anatomic and physiologic features. Structural and functional differences between the mature and immature myocardium, as well as different etiologies of neonatal heart failure, pose challenges for the clinician when evaluating and treating the clinical syndrome of heart failure. Anatomically, the newborn myocardium is disorganized in its str...

BACKGROUND Obtaining information on children's health and health events is heavily dependent on maternal report. Experience as to what factors influence accuracy of reporting varies, and few studies have examined the influence of current child health status on recall. METHODS A prospective cohort study involving 1833 children who were assessed in infancy and at 8 to 10 years of age was conduc...

Neurotoxic bilirubin is solely conjugated by UDP-glucuronosyltransferase (UGT) 1A1. Due to an inadequate function of UGT1A1, human neonates develop mild to severe physiological hyperbilirubinemia. Accumulation of bilirubin in the brain leads to the onset of irreversible brain damage called kernicterus. Breastfeeding is one of the most significant factors that increase the risk of developing ker...

Hypoxic ischemic encephalopathy is a serious condition affecting newborn infants which can result in death and disability. There is now strong clinical evidence that moderate post-asphyxial total body cooling or hypothermia in full term neonates results in long-term neuroprotection, allowing us to proclaim this innovative therapy as "standard of care." The treatment is a time-critical emergency...

During the past two decades, major progress has been made in understanding the plasma lipid transport system. Such advances have shown that the metabolic fate of plasma lipids in the form of plasma lipoproteins are subject to specific regulatory controls dictated largely by their composition, quantity, specific surface apolipoproteins, and several lipolytic enzymes. The lipid and apoprotein com...