Necrosis and cell death occur frequently in vari ous pathological conditions, including neoplasia; many tumors are composed of mixtures of neoplastic and non-neoplastic cells, necrotic cells, stremai, inflammatory, and blood cells. These cells, depending on metabolic factors and nutri tion, are in quite different phases of activity rang ing from the rapid growth of the neoplastic and regenerati...

Human T-cell lymphotropic virus type 1 (HTLV-1) induces adult T cell leukemia/lymphoma (ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and carrier. Approximately half of ATLL patients have direct skin involvement of neoplastic cells. However, there exist HTLV-1-associated reactive eruptions with a predominant infiltrate of non-neoplastic CD8+ T cells in ATLL, HAM/TSP...

objective(s): t-cell acute lymphoblastic leukemia (t-all) is an aggressive hematologic malignant tumor. administration of chemical compounds influencing apoptosis and t cell development has been discussed as promising novel therapeutic strategies. valproic acid (vpa) as a recently emerged anti-neoplastic histone deacetylase (hdac) inhibitor and pioglitazone (pgz) as a high-affinity peroxisome p...

Familial hemophagocytic lymphohistiocytosis (FHLH) with Epstein–Barr virus (EBV) infection can mimic chronic active EBV of T- and NK-cell type (CAEBV-T/NK) in its clinical manifestation pathomorphology. FHLH genetic susceptibility to has not been previously reported. The development conjunction is rare needs further investigation understand characterize it. We report a case that mimicked CAEBV-...

This study describes a case of giant cell osteosarcoma (GCO) localised on the right scapulae in six-year-old neutered male Scottish Fold cat. GCO is rare tumour domestic animals. also known as cell-rich osteosarcoma. Multinucleated cells and osteoid structures are observed GCO. The mass was 4.6 x 4.4 4.3 cm size very firm. Microscopically, fusiform spindle-shaped multinucleated were observed. T...

Gingival overgrowth commonly seen in clinics can be categorized as generalized or localized. Peripheral giant cell granuloma (PGCG) is tumor like, non-neoplastic reactive intra-osseous lesion occurring the gingiva alveolar mucosa and characterized by an un-encapsulated proliferation of mononuclear polygonal cells which are spindle-shaped with osteoclast-type multinucleated a vascular background...

Specific immunity refers to the ability of human body resist infection obtained by acquiring infection. It is generally formed after microbial and other antigenic material stimulation activation lymphocyte production immunoglobin typical this process. If specific immune response not correctly triggered, some neoplastic diseases (such as cancer) may develop tumor cell can escape response. wrongl...

Neoplastic transformation results in a wide variety of cellular alterations that impact the growth, survival, and general behavior of affected tissue. Although genetic alterations underpin the development of neoplastic disease, epigenetic changes can exert an equally significant effect on neoplastic transformation. Among neoplasia-associated epigenetic alterations, changes in cellular glycosyla...

Acid exerts pro-proliferative effects in Barrett's-associated esophageal adenocarcinoma cells. In non-neoplastic Barrett's epithelial (BAR-T) cells, in contrast, we have shown that acid exposure has antiproliferative effects. To explore our hypothesis that the acid-induced, antiproliferative effects are mediated by alterations in the proteins that regulate the G(1)-S cell cycle checkpoint, we e...