thymoma is the most common neoplasm of anterior mediastinum with incidence peaks during the fourth, fifth and sixth decades of life. two-thirds of patients are asymptomatic and identified accidentally by chest x-rays . of the total, 40-70 % of patients have one or more parathymic syndromes of which myasthenia gravis (mg) is the most common and reported in 10-50% . gullain-barre syndrome (gbs) h...

conclusions there was a significant association between pms scores and the prevalence of metabolic syndrome. further studies are needed to confirm and validate the relationships between lipid profile abnormalities and metabolic disorders with pms. objectives this study was designed to investigate the association of hormonal and metabolic factors with pms among iranian women of reproductive age....

Janssen, Luke J., Stuart J. Netherton, and Denise K. Walters. Ca21-dependent K1 channels and Na1-K1-ATPase mediate H2O2and superoxideinduced relaxations in canine trachealis. J. Appl. Physiol. 88: 745–752, 2000.—We examined the ionic mechanisms underlying the responses of canine trachealis to superoxide (generated in vitro by using xanthine oxidase or added exogenously) and peroxide (generated ...

Janssen, Luke J., Pierre A. Betti, Stuart J. Netherton, and Denise K. Walters. Superficial buffer barrier and preferentially directed release of Ca21 in canine airway smooth muscle. Am. J. Physiol. 276 (Lung Cell. Mol. Physiol. 20): L744–L753, 1999.—We examined cytosolic concentration of Ca21 ([Ca]i) in canine airway smooth muscle using fura 2 fluorimetry (global changes in [Ca]i), membrane cur...

severe overgrowth and tallness is very rare in human beings. the most common cause is gigantism due to the excessive secretion of the growth hormone, especially, before the closure of long bones’ epiphyseal growth plates. there are other rare disorders that are categorized on overgrowth syndromes. herein, we report an extremely rare, or even perhaps a unique, patient from iran. the clinical and...

The immunologic abnormalities in patients with allergic skin diseases occur as a consequence of primary defects residing within the epidermis, suggesting an association between skin barrier dysfunction and immune abnormalities (1). The skin barrier is located in the uppermost layers of the epidermis, the stratum corneum, with important elements: in-tracellular keratin filaments, intercellular l...

Netherton’s syndrome Cyclosporine Dr. A.A. Ramelet, 2, place Benjamin-Constant, CH-1003 Lausanne (Switzerland), Tel. 021 312 60 60, Fax 021 320 40 90 In 1958, Netherton [IJ reported a unique case of trichorrhexis nodosa ‘bamboo hairs’. Netherton’s syndrome (NS) consists of the triad of ichthyosiform dermatosis, multiple defects of the hair shaft (trichorrhexis invaginata) and an atopic diathesi...

Ichthyosis with confetti (IWC) is an autosomal dominant congenital ichthyosis also known as ichthyosis variegata or congenital reticular ichthyosiform erythroderma. It manifests at birth with generalized ichthyosiform erythroderma or with a collodion baby picture. The erythrodermic and ichthyotic phenotype persists during life and its severity may modify. However, the hallmark of the disease is...

macrophage activating syndrome (mas) is a life-threatening disease seen in autoimmune diseases including lupus erythematosus, rheumatoid arthritis, still's disease, polyarteritis nodosa. it is characterized by fever, pancytopenia, liver failure, coagulopathy, and neurologic symptoms and high serum ferritin. a 27 yr. old female patient was admitted in shahid mostafa khomeini hospital (tehra...