CC-BY 4.0 International license peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was not. Introduction " our incomplete studies do not permit actual classification; but it is better to leave things by themselves rather than to force them into classes which have their foundation only on paper " – Edouard Seguin 1 " The fundamental mi...

Learning Outcomes: 1. Describe the differences between the serial image of sensory input and multi-dimensional inputs. 2. List at least two ways that normal infants demonstrate the ability to shift from one sensory mode to another. 3. Describe two ways in which the therapist can utilize rhythm and timing of movement to achieve a desired response. 4. List at least 4 ways that the concepts in thi...

The term neurodevelopmental disorder encompasses a wide range of diseases, including recognizably distinct syndromes known to be caused by very rare mutations in specific genes or chromosomal loci, and also much more common disorders such as schizophrenia, autism spectrum disorders, and idiopathic epilepsy and mental retardation. After decades of frustration, the past couple of years have sudde...

s | 79 Abstract Background: Group I metabotropic glutamate receptor (mGluR1 and mGluR5) allosteric modulators are currently being investigated as novel therapeutics for the treatment of neurodevelopmental disorders such as schizophrenia, autism, depression (Cleva and Olive, 2011). Recent evidence suggests that allosteric modulators have adverse pharmacological effects when bound to the monomeri...

s | 79 Abstract Background: Group I metabotropic glutamate receptor (mGluR1 and mGluR5) allosteric modulators are currently being investigated as novel therapeutics for the treatment of neurodevelopmental disorders such as schizophrenia, autism, depression (Cleva and Olive, 2011). Recent evidence suggests that allosteric modulators have adverse pharmacological effects when bound to the monomeri...

BACKGROUND Early detection of neurodevelopmental disorders (NDDs) enables access to early interventions for children. We assess the Ages and Stages Questionnaire (ASQ)'s ability to identify children with a NDD in population data. METHOD Children 4 to 5 years old in the National Longitudinal Survey of Children and Youth (NLSCY) from cycles 5 to 8 were included. The sensitivity, specificity, po...

Understanding of human structural brain development has rapidly advanced in recent years, but remains fundamentally "localizational" in nature. Here, we use 376 longitudinally acquired structural brain scans from 108 typically developing adolescents to conduct the first study of coordinated anatomical change within the developing cortex. Correlation in rates of anatomical change was regionally ...

Purpose: Hypoplastic Left Heart Syndrome (HLHS) accounts for 7-9% of all congenital heart diseases. It is fatal unless surgically corrected. Survival has improved overtime. However, neurodevelopmental outcomes have not been known until recently. This paper discusses the neurodevelopmental outcomes of patients with HLHS and the factors that influence these outcomes. Methods: A search of the lite...