279–285. 9 Said SI, Rattan S. The multiple mediators of neurogenic smooth muscle relaxation. Trends Endocrinol Metab 2004; 15: 189–191. 10 Szema AM, Hamidi SA, Lyubsky S, et al. Mice lacking the VIP gene show airway hyperresponsiveness and airway inflammation, partially reversible by VIP. Am J Physiol Lung Cell Mol Physiol 2006; 291: L880–L886. 11 Hamidi SA, Prabhakar S, Said SI. Enhancement of...

Various cells and inflammatory mediators are involved in the initial pulpal responses to caries. This review focuses on the cellular, neuronal, and vascular components of pulpal innate responses to caries. Discussion will include dentinal fluid, odontoblasts, neuropeptides, and neurogenic inflammation, which are not classic immune components but actively participate in the inflammatory response...

The importance of the muscular factor, which is traditionally considered in myofascial pain syndrome (MFPS), development and maintenance musculoskeletal (MSP) actively discussed. hypothesis leading role trigger points (MTPs) muscle remains debatable. Probably, secondary to underlying disease. MTP phenomenon as an area hyperalgesia resulting from neurogenic inflammation muscles that were not ini...

Migraine is a neurovascular disorder that is characterized by unilateral, pulsatile headaches. Migraine due to its individual and social effects is known as a major cause of disability in the world. The main complication of this disease is chronification that is known as chronic migraine (CM). It seems that several factors contribute to migraine chronification such as age, female gender, obesit...

The neuropeptide substance P manifests its biological functions through ligation of a G protein-coupled receptor, the NK1R. Mice with targeted deletion of this receptor reveal a preponderance of proinflammatory properties resulting from ligand activation, demonstrating a neurogenic component to multiple forms of inflammation and injury. We hypothesized that NK1R deficiency would afford a simila...

how to cite this article: saeedi borujeni mj, esfandiary e, almasi dooghaee m. childhood neurogenic stuttering due to bilateral congenital abnormality in globus pallidus: a case report and review of the literature. iran j child neurol. autumn 2016; 10(4):75-79.   abstract objective the basal ganglia are a group of structures that act as a cohesive functional unit. they are situated at the base ...

BACKGROUND Neuropathic pain (NP) is partially mediated by neuroinflammatory mechanisms, and also modulates local neurogenic inflammation. Dietary lipids, in particular the total amount and relative proportions of polyunsaturated fatty acids (PUFAs) of the omega-3 and omega-6 families, have been reported to modify the threshold for thermal and mechanical allodynia in the partial sciatic nerve li...

The anti-inflammatory mechanisms of minocycline, an antibiotic used in the treatment of the inflammatory component of acne, are only partially understood. In addition to inflammation due to cytokines (IL-1, IL-6, TNF-alpha, etc.), recent studies have shown that neuropeptide-mediated neurogenic inflammation may play an important role in cutaneous inflammation. The purpose of this study was to in...