Introduction: According to our hypothesis, the mean platelet volume (MPV) value in migraine patients should be lower than healthy individuals due recurrent neuroinflammation during headache attacks. Therefore, this study aimed identify differences between MPV and other hemogram parameters pediatric with a control group. Material methods: This included total of 80 people, 40 subjects. Those hema...

Background: Periodontal disease(s) and metabolic illnesses negatively impact the quality of life and, eventually mental health. Objective: This study investigated effect Porphyromonas gingivalis (W83) oral infection on development Alzheimer’s disease (AD) pathophysiology in a wild-type obese, diabetic (db/db) mouse model. Methods: The db/db mice were either orally infected with P. Fusobacterium...

Abstract Neuroinflammation is involved in the aetiology of many neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease and motor neuron disease. Whether neuroinflammation also plays an important role pathophysiology frontotemporal dementia less well known. Frontotemporal a heterogeneous classification that covers subtypes, with main pathology known as lobar degeneration....

The most common dementias such as Alzheimer's disease, vascular dementia, Lewy body dementia, and frontotemporal dementia are associated with a decline in cognitive and social abilities. Although the molecular mechanisms of tissue damage in these dementias are not completely understood, these neurodegenerative illnesses share certain alterations such as neuroinflammation and gliosis. Increasing...

Aging is the main risk factor for Alzheimer’s disease (AD). With aging, inflammation has been recognized as potential trigger for starting the neurodegenerative cascade leading to neuronal death. Before Aβ and tau accumulation, evidence has put alterations of the cell cycle at the core of these processes. Still, a number of features of the cell cycle re-entry phenotype have remained elusive to ...

BACKGROUND Alzheimer's disease (AD) is the most common neurodegenerative disorder, neuropathologically characterized by aggregates of β-amyloid peptides, which deposit as senile plaques, and of TAU protein, which forms neurofibrillary tangles. It is now widely accepted that neuroinflammation is implicated in AD pathogenesis. METHOD Indeed, inflammatory mediators, such as cytokines and chemoki...

Brain diseases and disorders such as Alzheimer disease, Parkinson disease, depression, schizophrenia, autism, and addiction lead to reduced quality of daily life through abnormal thoughts, perceptions, emotional states, and behavior. While the underlying mechanisms remain poorly understood, human and animal studies have supported a role of neuroinflammation in the etiology of these diseases. In...

The prevalence of mental health disorders continues to rise worldwide, such that it is estimated that 1in 4 individuals will be affected by a mental health disorder at some point in their lifetime. Research has found that the most prevalent mental health disorders are depressive disorder. Depression is a common condition, particularly within the aging population. The development of depression, ...

Neuroimmunology and Neuroinflammation is an open access journal, with focuses on neuroimmunology neuroinflammation research, coverage extending to other basic clinical studies related neuroscience.

Microglia become activated during neuroinflammation and produce neurotoxic and neurotrophic factors, depending on whether they acquire M1 proinflammatory or M2 anti-inflammatory phenotypes. Astaxanthin (ATX), a natural carotenoid, has anti-inflammatory and neuroprotective effects. We investigated whether ATX could reverse M1/M2 polarization and suppress neuroinflammation via low-density lipopro...