Neuromuscular junctions (NMJs) are a special type of chemical synapse that transmits electrical stimuli from motor neurons (MNs) to their innervating skeletal muscle induce response. They an ideal model for the study synapses, given manageable size and easy accessibility. Alterations in morphology or function lead neuromuscular disorders, such as congenital myasthenic syndromes, which caused by...

Maintenance of DNA integrity is crucial for faithful transmission the genetic code from generation to generation. Our constantly under attack both endogenous and exogenous sources damage. To ensure genome stability, cells have developed elegant damage repair mechanisms. Defects in been linked several human diseases including promoting oncogenesis, heritable neurodegenerative neuromuscular cause...

Sugammadex was introduced to Royal Perth Hospital in early 2011 without access restriction. Two departmental audits (26-page online survey and 1-week in-theatre snapshot audit) were undertaken to investigate the change of beliefs and clinical practice related to the use of neuromuscular blocking agents at the Royal Perth Hospital since this introduction. Results were compared with data from 201...

effects of venom from black scorpion androctonus crasicuda (ac) were determined on isolated chick biventer cervices nerve-muscle and mouse hemidiaphragm preparations using twitch tension method. the isolated nerves were stimulated by electrical stimulator and response to each stimulus was recorded. the venom mainly acted prejunctionally to facilitate neuromuscular activity due to an increase in...

In spite of the available information about the development of Drosophila neuromuscular junctions, the correlation between nerve terminal morphology and maintenance of synaptic strength has still not been systematically addressed throughout larval development. We characterized the growth of the abdominal longitudinal muscle 6 (m6) and the motor terminals Ib and Is that innervate it within segme...

"In never considering neuromuscular disease to be untreatable, Yves Rideau has found ways to ameliorate every aspect of these conditions. His work has resulted in immeasurably enhancing the quality of life of his patients". This dedication included into the Guide to Evaluation in Management of Neuromuscular Diseases, 1999, made by a coworker who studied in Poitiers from 1981 to 1983, summarizes...

There are many causes of prolonged postoperative muscle weakness, including drugs, residual anesthetics, cerebrovascular events, electrolyte imbalance, hypothermia, and neuromuscular disease. Neuromuscular diseases are relatively rare, with the most common being myasthenia gravis and Lambert-Eaton myasthenic syndrome (LEMS). We report an unusual case in which a patient who was given a muscle re...

The anaesthetic management of children with neuromuscular diseases giving rise to hypotonia is associated with a variety of problems. Ketamine alone was given by the intravenous or intramuscular route to 32 children with Floppy Infant Syndrome for diagnostic muscle biopsy. The patients aged between three months and 12 yr and weighing 3.2 to 28 kg were studied over three years (1986-1988). The s...

Spinal muscular atrophy (SMA) is a neuromuscular disorder characterized by degeneration of alpha motor neurons resulting in hypotonia, progressive muscular weakness and atrophy.30 Spinal muscular atrophy is one of the leading hereditary causes of infant mortality,31 it comprises the second most common fatal progressive diseases after cystic fibrosis.28 Spinal muscular atrophy is the most common...

Neuromuscular scoliosis in a child presents as a diagnostic and therapeutic dilemma to the pediatric neurologist, the pediatric neurological surgeon, and the pediatric orthopaedist. Because of its progressive nature, it tends to be refractory to conservative management and requires active intervention. Neuromuscular scoliosis is a symptom, and the diseases leading to the deformity must be addre...