Environmental exposures transported across air, land and water can affect our health making us more susceptible to developing a disease. Therefore, researchers need face the complex task of integrating environmental linking them events with relevant spatiotemporal context for individuals or populations. We present usability evaluation approach study semantic framework (i.e. Knowledge Graph, Met...

The majority of phase III clinical trials use a 2-arm randomized controlled trial with 50% allocation between the control treatment and experimental treatment. sample size calculated for these normally guarantee power at least 80% certain Type I error, usually 5%. However, calculations, do not typically take into account total patient population that may benefit from investigated. In this artic...

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are near universally fatal conditions if untreated. Although effective therapeutic options are available for these diseases, treatment regimens are associated with both short- and long-term adverse effects. The recent identification of effective B-cell-targeted therapy with an anti-CD20 monoclonal antibody has transforme...

The aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis has not been well defined. Here we review two factors which may play a role in the pathogenesis of the disease: genetics and infection. In particular, we discuss the role of autoantibodies to LAMP-2, which may arise following infection with Gram-negative bacteria, and may contribute to the development of...

Steadily growing knowledge about pathogenetic mechanisms in autoimmune rheumatic diseases (RDs) has paved the way to different therapeutic approaches. In particular, availability of biologics on market dramatically modified natural history chronic inflammatory with a meaningful impact patients’ quality life. Among wide spectrum available biological treatments, rituximab (RTX), initially used tr...

Objetivo: Analisar o padrão de tratamento das Vasculite Associada a Autoanticorpos (VAA) associada ao Anticorpos Anti-Citoplasma Neutrófilos (ANCA) relacionando com faixa etária e diagnóstico. Métodos: As bases dados National Library of Medicine, Biblioteca Virtual em Saúde Directory Open Access Journals os descritores “Vasculitis And Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis”,...