Introduction Patent ductus arteriosus (PDA) is due to the failure of the ductus arteriosus to close after birth, and its incidence being inversely related to gestational age and birth weight (1,2). The incidence of PDA in term infants has been estimated to be 57 per 100 000 live births, whereas every third preterm infant with a birth weight of 501 to 1500 g can be expected to have a persistent ...

1. Myofibrillar protein breakdown was calculated from the urinary excretion ratio of NT- methylhistidine (3-methylhistidine) to creatinine in newborn premature and full-term infants. Representative values were obtained from single voidings provided that the infant's metabolic status was stable. 2. NT- Methylhistidine in infant urine was measured by a rapid Auto Analyser method and shown to give...

Children born preterm often exhibit reduced lung function and increased severity of response to respiratory viruses, suggesting that premature birth has compromised proper development of the respiratory epithelium and innate immune defenses. Increasing evidence suggests that premature birth promotes aberrant lung development likely due to the neonatal oxygen transition occurring before pulmonar...

PURPOSE To study the immunogenicity and the stability of the porcine pulmonary surfactant preparation produced by the Instituto Butantan. METHOD Immunogenicity assay: Sixteen New-Zealand-White rabbits (1000 g body weight) were divided into 4 study groups. Each group was assigned to receive either a) Butantan surfactant, b) Survanta (Abbott Laboratories), c) Curosurf (Farmalab Chiesi), or d) n...

BACKGROUND Alveolarization requires coordinated extracellular matrix remodeling, a process in which matrix metalloproteinases (MMPs) play an important role. We postulated that polymorphisms in MMP genes might affect MMP function in preterm lungs and thus influence the risk of bronchopulmonary dysplasia (BPD). METHODS AND FINDINGS Two hundred and eighty-four consecutive neonates with a gestati...

We present a case of one-day-old newborn, without prenatal diagnosis, referred to our cardiologic intensive care unit in critical condition presenting sub-cyanosis and peripheral oxygen saturation 80%. Echocardiography diagnosis was tricuspid valve dysplasia with severe regurgitation, functional pulmonary atresia intact ventricular septum reversal flow the large patent ductus arteriosus (PDA). ...

Continuous noninvasive monitoring of oxygenation in premature neonates with respiratory distress is essential to avoid the potential complications of hypoxemia and hyperoxia. The accuracy and reliability of pulse oximetry (using an Ohmeda Biox) was evaluated in 15 premature neonates. Pulse oximetry oxygen saturation readings closely approximated arterial oxygen saturation values analyzed by an ...

BACKGROUND Premature infants are at high risk for developmental delay and cognitive dysfunction. Besides medical conditions, growth restriction is regarded as an important risk factor for cognitive and neurodevelopmental dysfunction throughout childhood and adolescence and even into adulthood. In this study, we analyzed the relationship between post-discharge body weight and psychomotor develop...

Genetic abnormalities of pulmonary surfactant were identified by DNA sequence analysis in 14 (12 full-term, 2 preterm) of 17 newborn infants with fatal respiratory distress of unknown etiology. Deficiency of adenosine triphosphate-binding cassette protein, member A3 (n = 12) was a more frequent cause of this phenotype than deficiency of surfactant protein B (n = 2).