A healthy endothelium is essential for vascular homeostasis, and preservation of endothelial cell function is critical for maintaining transplant allograft function. Damage to the microvascular endothelial cells is now regarded as a characteristic feature of acute vascular rejection, an important predictor of graft loss. It is also linked with transplant vasculopathy, often associated with chro...

Migraine shows strong familial aggregation. However, the number of genes involved in the disorder is unknown and not identified. Nitric oxide is involved in the central processing of pain stimuli and plays an important role in the regulation of basal or stimulated vasodilation. Nitric oxide synthase, which controls the synthesis of nitric oxide, could possibly be a cause, or candidate gene, in ...

NADPH diaphorase histochemistry selectively labels a number of discrete populations of neurons throughout the nervous system. This simple and robust technique has been used in a great many experimental and neuropathological studies; however, the function of this enzyme has remained a matter of speculation. We, therefore, undertook to characterize this enzyme biochemically. With biochemical and ...

ABSTRACT We analyzed the mechanisms underlying enhanced IgA production in cells of Peyer's patch via membrane vesicles derived from Lactobacillus sakei subsp. NBRC 15893. Depletion CD11c+ suppressed mediated by vesicles. Meanwhile, stimulation bone-marrow–derived dendritic with increased gene expression inducible nitric oxide synthase, retinaldehyde dehydrogenase 2, and several inflammatory cyt...

Nitric Oxide as an Efferent Modulator of Circadian Pacemaker Neurones in the Eye of the Marine Mollusc Bulla gouldiana. Background: Nitric oxide synthase NOS is essential for the synthesis of nitric oxide. The diurnal oscillation of NOS in the hippocampus is.Nitric oxide NO plays an important role in phase-shifting of circadian neuronal activities in the suprachiasmatic nucleus and circadian be...

Ascorbic acid and nitric oxide are known to play important roles in epilepsy. The aim of present study was to identify the involvement of nitric oxide (NO) in the anticonvulsant effects of ascorbic acid on penicillin-induced epileptiform activity in rats. Intracortical injection of penicillin (500, International Units (IU)) into the left sensorimotor cortex induced epileptiform activity within ...

Buckwalter, John B., Jessica C. Taylor, Jason J. Hamann, and Philip S. Clifford. Role of nitric oxide in exercise sympatholysis. J Appl Physiol 97: 417–423, 2004. First published March 12, 2004; 10.1152/japplphysiol.01181.2003.—The production of nitric oxide is the putative mechanism for the attenuation of sympathetic vasoconstriction (sympatholysis) in working muscles during exercise. We hypot...

To the Editor: We read with interest 2 recent reports published in Circulation. We believe that the work of Qian et al1 and Ridker et al2 has an important connection in light of our recent findings.3 Qian and coworkers1 showed that in cholesterol-fed rabbits, increased nitric oxide production, via nitric oxide synthase gene transfer, produced rapid amelioration of several markers of atheroscler...

OBJECTIVE Obstructive sleep apnea syndrome is characterized by repetitive obstruction of the upper airways, and it is a risk factor for cardiovascular diseases. There have been several studies demonstrating low levels of nitric oxide in patients with obstructive sleep apnea syndrome compared with healthy controls. In this study, we hypothesized that reduced nitric oxide levels would result in h...

Under normal physiological conditions activation of nitric oxide synthases produces both nitric oxide and superoxide in equimolar concentrations (Figure 1). We propose a hypothesis that in hypoxia-reoxygenation injury this balanced co-production of nitric oxide and superoxide is disturbed and results in pathological effects. Specifically, under hypoxic conditions nitric oxide synthase is activa...