Previous studies have suggested that (1) nitroglycerin causes vasodilatation by interacting with sulfhydryl groups in vascular smooth muscle, thereby activating guanylate cyclase and increasing the intracellular concentration of cyclic GMP, and (2) N-acetylcysteine, a source of sulfhydryl groups, potentiates the peripheral vasodilatory effect of nitroglycerin. This study was performed to explor...

The article presents the history of study and registration in USSR buccal form nitroglycerin (trinitrolong) 1970s 1980s, based on a number author's publications, documentary evidence oral stories participants clinical trials. specifics passage main stages new pharmacological agent Soviet control authorization system from idea to introduction drug into practice are described. Some reasons for la...

The rondo is a musical form in which a single recurrent theme alternates with different melodic motifs that are each distinct from one another. The recurrent theme is typically repeated multiple times, providing both the overall unity for the musical movement and a familiar musical destination to which the piece returns after the presentation of distinct interspersed themes. The parallels betwe...

PURPOSE. This study investigates the influence of sublingual nitroglycerin spray on the lumen diameter, number of side branches visualized, average vessel length shown on 3.0-T contrast-enhanced whole-heart coronary magnetic resonance angiography (WH-CMRA). BACKGROUND. Organic nitrates are potent vasodilators that dilate both normal and abnormal coronary arteries by relaxing vascular smooth mus...

To study the vasomotility of normal and diseased coronary arteries during dynamic exercise, symptom-limited supine bicycle exercise during cardiac catheterization was performed by 18 patients with classic angina pectoris. The cardiovascular response was assessed by hemodynamic measurements and computer-assisted determination of normal and stenotic coronary artery luminal areas from biplane coro...

We studied the effect of nitroglycerin-induced decreases in mean arterial pressure (MAP) on myocardial salvage. Two hours after occlusion of the left anterior descending coronary artery, 65 conscious dogs were randomly allocated to receive 4 hr intravenous infusions of saline (group 1, 19 dogs), or nitroglycerin in doses to decrease MAP by 10% (group 2, 18 dogs), 25% (group 3, 14 dogs), and 50%...

The therapeutic effect of nitroglycerin is geneially attributed to its coronary dilator effect alone. In contrast, it could be shown that nitroglycerin also counteracts the chronotropic as wvell as the electiocardiographic T-wave (leplessing effects of epinep)hline, arterenol and caldiac syml)athinl upon the heart. Accordingly, its therapeutic action in angina pectoris is suspected as being lar...

were studied. Observations were made upon changes in heart rate, myocardial oxygen consumption, systolic vigor, and the electrocardiograms. Data are presented showing the effects of nitroglycerin and adrenergic agents when given separately and in combination. Results indicate that in dogs, nitroglycerin produces no antiadrenergic effects on the myocardium. The suggestion is made that the T wtav...