Despite the fact that it was put on market more than 60 years ago, hydrochlorothiazide (HCT) is still one of most important antihypertensive drugs. Due to its chemical structure, which contains secondary aryl-alkyl-amino moiety, vulnerable formation N-nitrosamine drug substance-related impurity (NDSRI) N-nitroso-hydrochlorothiazide (NO-HCT). In our study, we reveal NO-HCT degrades rapidly at pH...

The O6-alkylguanosine adduct O6-carboxymethyldeoxyguanosine (O6-CMdG) has been detected at elevated levels in blood and tissue samples from colorectal cancer patients healthy volunteers after consuming red meat. diazo compound l-azaserine leads to the formation of O6-CMdG as well corresponding methyl O6-methyldeoxyguanosine (O6-MedG) cells is therefore wide use a chemical probe cellular studies...

A highly selective, sensitive, rapid and economical differential pulse polarographic method has been developed for the determination of trace amounts of antimony in various standard alloys and biological samples after adsorption of its 2-nitroso-1-naphthol-4-sulfonic acid - tetradecyldimethylbenzylammonium chloride on microcrystalline naphthalene in the pH range of 7.5-11.0. After filtratio...

We report for the first time voltammetric/electrochemiluminescent sensors applied to predict genotoxicity of N-nitroso compounds bioactivated by human cytochrome P450 enzymes.

Electrochemistry is a valuable tool used by modern synthetic chemists who use electricity to facilitate redox reactions. In this image, created Karrar Nadhom, the dragon provides electrical surge create reaction between sodium nitrite and secondary amine, which are fused form N-nitroso product. Despite dragons being extinct in most parts of world, title an ecologically green process, as indicat...

Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) is a widely used explosive that is present in soils at a number of military sites, including training and testing ranges. Because of its relatively weak adsorption to soil, RDX frequently migrates through the unsaturated zone and causes groundwater contamination. In the environment, RDX can transform to produce mono-, di-, and tri-nitroso derivative...

Nitrosamine impurities are potentially genotoxic which considered under cohort of concern as per ICH M7 guidelines and need to be controlled at trace levels during quantification in drug substances products for safe human consumption. Recent regulatory requirements also suggest the have highly sensitive analytical methods accurate impurities. In this paper we presented simple, rapid ultra-sensi...