Expression of Nodal, a Transforming Growth Factor-beta (TGF-β) related growth factor, is associated with aggressive melanoma. Nodal expression in adult dysplastic nevi may predict the development of aggressive melanoma in some patients. A subset of pediatric patients diagnosed with giant or large congenital melanocytic nevi (LCMN) has shown increased risk for development of melanoma. Here, we i...

NOVEL BIOCHEMICAL AND PHENOTYPICAL FINDINGS ON THE NODALSIGNALING COMPONENTS LEFTY AND CRIPTObyAMAPOLA BALANCIODecember 2014Advisor: Dr. William Branford, Jr.Major: Biological Sciences (Molecular and Developmental Biology)Degree: Master of ScienceNodal, a Transforming Growth Factor-β (TGF-B), is a key regulator of properdevelopment along with its atypical...

In this paper, the asymptotic representation of the corresponding eigenfunctions of the eigenvalues has been investigated. Furthermore, we obtain the zeros of eigenfunctions.

Accumulation of voltage-gated sodium (Na(v)) channels at nodes of Ranvier is paramount for action potential propagation along myelinated fibers, yet the mechanisms governing nodal development, organization, and stabilization remain unresolved. Here, we report that genetic ablation of the neuron-specific isoform of Neurofascin (Nfasc(NF¹⁸⁶)) in vivo results in nodal disorganization, including lo...

The Nodal and Hedgehog signaling pathways influence dorsoventral patterning at all axial levels of the CNS, but it remains largely unclear how these pathways interact to mediate patterning. Here we show that, in zebrafish, Nodal signaling is required for induction of the homeobox genes nk2.1a in the ventral diencephalon and nk2.1b in the ventral telencephalon. Hedgehog signaling is also require...

Introduction: One of the fundamental structural elements of the cell is the cytoskeleton. Along with myosin, actin microfilaments are responsible for cellular contractions, and their organization may be related to pathological changes in myocardial tissue. Due to the complexity of factors involved, numerical modeling of the cytoskeleton has the potential to contribute to a better understanding ...

With the advantages of lightweight and high stowing efficiency, origami membrane has a broad application prospect in space structure. As an improvement existing deployment simulations, behavior crease is considered both static dynamic simulation are conducted this paper. The modeled as flexible multibody system its simulated based on absolute nodal coordinate formulation. nonlinear effect to re...

Since the discovery of first topological material 15 years ago, search for realizations novel phases has become driving force field. While oftentimes we new materials, forget that well established materials can also display very interesting properties. In this work, revisit CoS$_2$ , a metallic ferromagnetic pyrite been extensively studied in literature due to its magnetic We study features ele...

With the increasing amount of space debris, it is necessary to develop debris active cleaning technology. The netted pocket system a flexible mechanism which can be used capture non-cooperative target flexibly due advantages having stable structure, strong adaptability and large range. In this paper, dynamics capturing are investigated. model established based on absolute nodal coordinate formu...

Two cases of Kikuchi disease showed variable nodal enhancing features, including homogeneous enhancement and focal or extensive nodal necrosis on contrast-enhanced CT scans. At MR imaging, the area of central necrosis was isointense or hypointense on T1-weighted images and had a lower signal than nonnecrotic areas on T2-weighted images. The CT appearance of Kikuchi disease can be variable and c...