For regulated secretion, mast cells and several other cell types utilize compound exocytosis, a combination of granule-plasma membrane and granule-granule fusions. The molecular machinery that controls this massive export process has not been identified. We report that SNAP-23, a t-SNARE related to SNAP-25, relocates in response to stimulation from plasma membrane lamellipodia-like projections ...

OBJECTIVES To investigate the effect of different induced head-neck-jaw postures on head-neck relocation error among healthy subjects. METHODS 30 healthy adult male subjects participated in this study. Cervicocephalic kinesthetic sense was measured while standing, habitual sitting, habitual sitting with clenched jaw and habitual sitting with forward head posture during right rotation, left ro...

Given a fixed budget, the generic relocation problem seeks to determine a feasible reconstruction sequence of old buildings for a public housing project. The feasibility issue can be resolved because it is mathematically equivalent to makespan minimization in a two-machine flowshop. In this paper, we consider the variant where multiple working crews are available for the redevelopment project. ...

The paradigm of service-orientation promises a significant ease of use in creating and managing distributed software systems. A very important aspect here is that also application domain experts and stakeholders, who are not necessarily skilled in computer programming, get a chance to create, analyze, and adapt distributed applications. However, up to now, service-oriented architectures have be...

This work describes the application of hydrodynamic (ELCIRC) and transport (VELA and VELApart) models to the Ria Formosa lagoon (Portugal) to study the impact of the relocation of the Ancão Inlet. Located in the south of Portugal, this lagoon is a mesotidal barrier island system that communicates with the sea through 6 inlets. The Old Ancão Inlet was artificially closed and the New Ancão Inlet ...

Previous studies have indicated that glomerular podocyte injury serves a crucial role in proteinuria during the process of chronic kidney disease. The slit diaphragm of podocytes forms the final barrier to proteinuria. Dendrin, a constituent of the slit diaphragm protein complex, has been observed to relocate from the slit diaphragm to the nuclei in injured podocytes and promote podocyte apopto...

The issue of relocation presents courts and child custody evaluators with dilemmas on the issue of allowing a child to move with a parent to a new community and how to craft long-distance parenting plans if relocation is allowed. The issue of the potential effects of residential moves on children of divorce has focused on the importance of the child–nonresidential parent relationship. The resea...

Relocation is an increasingly prominent conservation tool for a variety of wildlife, but the technique also is controversial, even among conservation practitioners. An organized framework for addressing the moral dilemmas often accompanying conservation actions such as relocation has been lacking. Ecological ethics may provide such a framework and appears to be an important step forward in aidi...