Identification of prognostic and predictive biomarkers is important for targeting treatments to patients and for the design and analysis of randomised controlled trials. Cox proportional hazards modelling is a standard method for assessing prognostic value of clinical biomarkers where time to occurrence of an event is the primary outcome of interest. An important issue in the analysis of progno...

this paper deals with ridge estimation of fuzzy nonparametric regression models using triangular fuzzy numbers. this estimation method is obtained by implementing ridge regression learning algorithm in the la- grangian dual space. the distance measure for fuzzy numbers that suggested by diamond is used and the local linear smoothing technique with the cross- validation procedure for selecting t...

a pedigree file consisting of 5860 individuals, 167 sires and 1582 dams collected at makooei sheep breeding station (msbs) during a period of 24 years (1990 to 2013) was used to calculate the inbreeding coefficients to reveal any probable effects of inbreeding (f) on the studied traits. the studied traits were classified to the five main groups including body weight, kleiber ratio, body measure...

abstract   objective: to evaluate the association of base deficit (bd) with mortality in traumatized children, and to assess this association in a subgroup of patients with traumatic brain injury (tbi).   methods: in this cross-sectional study performed prospectively on a convenience sample of patients under 16 years of age with trauma presenting to an academic level іі trauma center, we obtain...