Recent years show an increase in the popularity of online social networking among the younger generation that opens up possibilities for educators to use it as a higher education platform. The focus of this paper is to highlight some open research questions in the context of knowledge management in higher education with the use of online social networking. Analysis of current research reveals t...

Context. Bright-rimmed clouds (BRCs) are isolated molecular clouds located on the edges of evolved HII regions. Star formation within these clouds may have been triggered through the propagation of photoionisation-induced shocks driven by the expansion of the HII region. Aims. The main focus of this paper is to investigate the current level of star formation within a sample of southern hemisphe...

BACKGROUND GNE myopathy is characterized by early-adult-onset distal myopathy sparing quadriceps caused by mutations in the GNE gene encoding UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, an enzyme in the sialic-acid synthesis pathway. CASE REPORT A 27-year-old Korean woman presented a rapid deterioration in strength of the distal lower limbs during her first pregnancy. She ...

A new conception of knowledge and knowledge conversions is introduced. It is represented by a knowledge cube, a three-dimensional model of knowledge with types, kinds and qualities, and allows a description of general knowledge conversions between those. Through this conception we gain a sound basis for knowledge management. We can describe knowledge-intensive business processes in a company, b...

Recent biochemical characterization of the T23-encoded Qa-1 molecule revealed an additional higher molecular mass species of 50 kD coprecipitated with the 48-kD Qa-1 molecule in H-2b and H-2d mouse strains. We now demonstrate that the 50-kD protein coprecipitated with Qa-1 is the class I-a antigen Ld in all H-2Ld-positive mouse strains examined. Furthers analyses of a panel of recombinants reve...

Nemaline myopathy (NM) is a congenital myopathy that can result in lethal muscle dysfunction and is thought to be a disease of the sarcomere thin filament. Recently, several proteins of unknown function have been implicated in NM, but the mechanistic basis of their contribution to disease remains unresolved. Here, we demonstrated that loss of a muscle-specific protein, kelch-like family member ...

Purpose: Quantitative susceptibility mapping (QSM) enables cerebral venous characterization and physiological measurements, such as oxygen extraction fraction (OEF). The exquisite sensitivity of QSM to deoxygenated blood makes it possible to image small veins; however partial volume effects must be addressed for accurate quantification. We present a new method, Iterative Cylindrical Fitting (IC...

We report the case of a 69-year-old woman with proximal limb muscle weakness, who received post-operative chemotherapy for uterine cancer. Her serum creatinine kinase level was high (10,779 mg/dL) and a muscle biopsy from her left biceps revealed various sizes of muscle fibers accompanied by necrotic and regenerating fibers. She was positive for anti-3 hydroxy-3-methylglutary-coenzyme A reducta...

In vivo QSM in early-stage Alzheimer’s disease reveals magnetostatic alterations in the basal ganglia and beyond Julio Acosta-Cabronero, Guy B Williams, Arturo Cardenas-Blanco, and Peter J Nestor Brainplasticity & Neurodegeneration, German Center for Neurodegenerative Diseases (DZNE), Magdeburg, Saxony-Anhalt, Germany, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, Cambridges...