RNA sequencing (RNA-Seq) is the current method of choice for characterizing transcriptomes and quantifying gene expression changes. This next generation sequencing-based method provides unprecedented depth and resolution. The negative binomial (NB) probability distribution has been shown to be a useful model for frequencies of mapped RNA-Seq reads and consequently provides a basis for statistic...

In this paper, we are concerned with the situations, where sometimes value two is reported erroneously as one in relation to size biased generalized negative binomial distribution (SBGNBD) with probability αα. We have obtained the Maximum likelihood estimator and Bayes estimator under general entropy loss function. A simulated study is carried out to access the performance of the maximum likeli...

The number of new gadolinium-enhancing lesions discovered via magnetic resonance imaging is a well-established outcome for multiple sclerosis studies, especially Phase II Studies. Due to the high cost of magnetic resonance imaging scans, many investigators select participants for the presence of lesions. While this selection procedure is thought to improve the power of inferences, the effect of...

A b s t r a c t . In this paper, we investigate the exact distribution of the waiting time for the r-th t-overlapping occurrence of success-runs of a specified length in a sequence of two state Markov dependent trials. The probability generating functions are derived explicitly, and as asymptotic results, relationships of a negative binomial distribution of order k and an extended Poisson distr...

BACKGROUND Limited information on oral health status for young adults aged 18 year-olds is known, and no available data exists in Hong Kong. The aims of this study were to investigate the oral health status and its risk indicators among young adults in Hong Kong using negative binomial regression. METHODS A survey was conducted in a representative sample of Hong Kong young adults aged 18 year...

Various statistical methods have been used to measure the impact of treatment on chronic obstructive pulmonary disease (COPD) exacerbations. Poisson regression has recently been recommended as the appropriate method but the model does not satisfactorily account for variability between patients. In contrast, use of a negative binomial model, which corresponds to assuming a separate Poisson param...

Usual approaches for estimating the variance of a standardized rate may not be applicable to rates of recurrent events. Where individuals are prone to repeated health events, Greenwood and Yule (J R Stat Soc [A], 1920;83:255-79) advocated use of the negative binomial distribution to account for departures from the assumption of randomness of recurrent events required by the Poisson distribution...

The Poisson regression model is a simple count data that combines models in which the response variable form of counts rather than fractional numbers generalized linear (GLMs) . Three (Poisson regression, quasi-Poisson and negative binomial regression) were compared r packages applied to sample COVID-19 this study. was shown be best most efficient other models.