نتایج جستجو برای: normoxia
تعداد نتایج: 2771 فیلتر نتایج به سال:
The aim of the present study was to investigate regulatory relationships among hypoxia-inducible factor-1α (HIF-1α), microRNA and erythroid transcription factors. K562 cells were transfected with HIF-1α knockout or with overexpression lentivirus of plasmid (MOI 10). The cells were divided into 3 groups: the negative control, overexpressing and interference groups. The cells were cultured under ...
Abstract Study question To determine whether hypoxic ovarian damage is due to increased growth and follicles “burnout” or apoptosis, this age dependent. Summary answer Direct tissue hypoxia causes activation recruitment of dormant without apoptotic changes. This effect dependent, more pronounced in adult- versus newborn ovaries. What known already In a previous study we have shown that perinata...
Background Many patients with pulmonary arterial or chronic thromboembolic hypertension (PH) wish to travel altitude by airplane, but their risk of hypoxia-related adverse health effects is insufficiently explored. Research Question How does hypoxia, compared normoxia, affect constant work-rate exercise test (CWRET) time in PH, and which physiologic mechanisms are involved? <h...
AMP-activated protein kinase (AMPK) is a major sensor and regulator of the energetic state of the cell. Little is known about the specific role of AMPKalpha(2), the major AMPK isoform in the heart, in response to global ischemia. We used AMPKalpha(2)-knockout (AMPKalpha(2)(-/-)) mice to evaluate the consequences of AMPKalpha(2) deletion during normoxia and ischemia, with glucose as the sole sub...
INTRODUCTION Exercise-induced proteinuria is predominantly caused by alterations in renal hemodynamics. The present study was conducted to determine the effect of aerobic exercise in hypoxia on proteinuria and hematuria. MATERIALS AND METHODS The study population consisted of 17 physically trained healthy young men. They were asked to attend in 4 sets of 30-minute running sessions, separated ...
When oxygen supply to tissues is limiting, mitochondrial respiration and ATP production are compromised. To assess the bioenergetic consequences under normoxia and hypoxia, quantitative evaluation of mitochondrial oxygen kinetics is required. Using high-resolution respirometry, the "apparent K (m)" for oxygen or p (50) of respiration in 32D cells was determined at 0.05 +/- 0.01 kPa (0.4 mmHg, 0...
Kubo M, Li TS, Suzuki R, Shirasawa B, Morikage N, Ohshima M, Qin SL, Hamano K. Hypoxic preconditioning increases survival and angiogenic potency of peripheral blood mononuclear cells via oxidative stress resistance. Am J Physiol Heart Circ Physiol 294: H590–H595, 2008. First published December 21, 2007; doi:10.1152/ajpheart.00856.2007.—Cell-based angiogenesis is a promising treatment for ischem...
BACKGROUND Hypoxia and high altitudes affect various organs, which impairs important physiological functions, such as a disruption of the intestinal barrier mediated by increased translocation of bacteria and increased circulating endotoxin levels. Physical exercise can alter endotoxin concentration in normoxia. The aim of this study is to evaluate the effects of moderate exercise on endotoxin ...
Epithelial mesenchymal transition (EMT) is considered to be correlated with malignancy of cancer cells and responsible for cancer invasion and metastasis. We previously reported that distant metastasis was associated with hypoxia in gastric cancer. We therefore investigated the effect of hypoxic condition on EMT of gastric cancer cells. Gastric cancer cells were cultured in normoxia (21% O2) or...
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