assay (R.I.A.) for estimation of plasma concentrations of nortriptyline and amitriptyline in monitoring response of patients receiving these drugs. However, a wide range of monoaminereuptake-inhibiting drugs is now used in treatment of depressive illness, and an advantage of some other analytical methods, such as the gas-liquid chromatography method described by Gifford et al.,’ is that they ca...

Non puerperal lactation or galactorrhea is a well known side effect of antipsychotic drugs but has been infrequently described with the use of antidepressants. In past few decades, there have been emerging trend of isolated case reports of selective serotonin reuptake inhibitors induced non puerperal lactation. We report a case of non puerperal lactation following usage of second generation tri...

High-performance thin-layer chromatography was used to determine chlorpromazine, amitriptyline, nortriptyline, imipramine, desipramine, phenobarbital, and phenytoin in plasma, to demonstrate the utility of this technique for routine analysis. We quantitated the separated components by use of ultraviolet reflectance spectrometry with detection limits as low as 1 microgram/liter. Regressions of p...

A 70-year-old female patient was admitted to the geriatrics department with an overall deterioration, including lethargy, and with recurrent syncope. She had no palpitations or chest pain or other symptoms preceding the syncopal episodes. She is known with a history of an anterior myocardial infarction more than 20 years ago and psychotic depression. Her current medication consisted of lithium ...

We describe a comprehensive gas chromatographic analysis for therapeutic concentrations of amitriptyline, nortriptyline, imipramine, desipramine, doxepin, and desmethyldoxepin in plasma, with use of a nitrogen detector. All these drugs are extracted and chromatographed under identical conditions. Each tertiary amine tricyclic is well resolved from its secondary amine metabolite on a mixed-phase...

Tricyclic antidepressants (TCAs) include imipramine, desipramine, amitriptyline, nortriptyline, doxepin, trimipramine, protriptyline, and clomipramine 1) . Among these, imipramine was first synthesized in 1948. However, it was not until 1958 that its antidepressant affects in humans were recognized. Since then, it has been the prototype TCA. Imipramine is used for the treatment of non-bipolar d...

Pharmacologic therapy for neuropathic pain – A number of medications have proved in randomized trials to be useful in the treatment of painful diabetic neuropathy. These medications include: Tricyclic antidepressants (amitriptyline, nortriptyline, imipramine); Anticonvulsants (gabapentin, pregablin, sodium valproate, lamotrigine); SSRI antidepressants; Opioids (oxycodone, morphine). All these d...