Flexible Sensor for Human Motion Monitoring In article number 2200487, Yongqin Hu, Yufei Liu, and co-workers develop a novel rapid synthetic method, without any additional heat or light, to fabricate MXene-based hydrogels. Adding the Fe3O4-COOH@MXene precursor solution (silk fibroin@acrylamide) spontaneously generates large of hydroxyl radicals, as well heat, which accelerates formation

Bioorthogonal uncaging strategies have recently emerged as an experimental therapeutic approach to control drug release. Herein we report a novel masking strategy that enables to modulate the metal chelating properties of hydroxamic acid groups by bioorthogonal chemistry using Pd-functionalized resins. This novel approach allowed to devise an inactive precursor of the histone deacetylase inhibi...

In the last decade, a new serine protease inhibitor family has been described in arthropods. Eight members of the family were purified from locusts and share a conserved cysteine array (Cys-Xaa(9-12)-Cys-Asn-Xaa-Cys-Xaa-Cys-Xaa(2-3)-Gly-Xaa(3-6)-Cys-Thr-Xaa3-Cys) with nine inhibitory domains of the light chain of the crayfish protease inhibitor, pacifastin (PLDs; pacifastin light chain domains)...

The adverse effects of chemotherapy on normal cells of the body create substantial clinical problems for many cancer patients. However, relatively little is known about the effects, other than promotion of cell death, of such agents on the function of normal precursor cells critical in tissue homeostasis and repair. We have combined mathematical and experimental analyses to identify the effects...

Ivabradine (Corlanor®), is a chiral benzocycloalkane currently employed and commercialized for the treatment of chronic stable angina pectoris reduction in sinus tachycardia. The eutomer (S)-ivabradine usually produced via resolution intermediates, by employing enantiopure auxiliary molecules or through preparative HPLC separations. Recently, more sustainable biocatalytic approaches have been r...

BACKGROUND MicroRNAs (miRNAs) are small, endogenously transcribed, non-protein-coding RNAs that play important roles in regulation of gene expression in animals and plants. Here, selective constraints on the novel precursor microRNA159 (pre-miR159) gene were investigated in 42 Phalaenopsis species (Orchidaceae). METHODS/RESULTS A novel precursor microRNA159 gene was isolated from 42 Phalaenop...

UNLABELLED The adverse effects of chemotherapy on normal cells of the body create substantial clinical problems for many cancer patients. However, relatively little is known about the effects, other than promotion of cell death, of such agents on the function of normal precursor cells critical in tissue homeostasis and repair. We have combined mathematical and experimental analyses to identify ...