To clarify the role of neuropeptide Y (NPY) in the regulation of the reproductive axis, these experiments evaluated the extent to which reproductive hormone secretions may be compromised in the absence of NPY expression. In NPY knockout (NPY-KO) and wild-type (WT) mice, hormone secretions were analyzed under conditions of basal release, following ovariectomy (OVX), in proestrus, after estrogen ...

BACKGROUND Neuropeptide Y (NPY) has been implicated in the modulation of pain. Under normal conditions, NPY is found in interneurons in the dorsal horn of the spinal cord and in sympathetic postganglionic neurons but is absent from the cell bodies of sensory neurons. Following peripheral nerve injury NPY is dramatically upregulated in the sensory ganglia. How NPY expression is altered in the pe...

Ma huang, the dried plant stem of ephedra intermedia Schrenk et C.A., contains an ephedrine-type alkaloid and has been used for weight loss. Neuropeptide Y (NPY), a 36-amino acid peptide, is concentrated in the hypothalamus and stimulates feeding desire. In this study, the effect of ma huang on the expressions of NPY in the hypothalamus of rats was investigated using immunohistochemistry. Food-...

Stress and anxiety-related behaviors controlled by the basolateral amygdala (BLA) are regulated in vivo by neuropeptide Y (NPY) and corticotrophin-releasing factor (CRF): NPY produces anxiolytic effects, whereas CRF produces anxiogenic effects. These opposing actions are likely mediated via regulation of excitatory output from the BLA to afferent targets. In these studies, we examined mechanism...

PURPOSE To characterize the potential for neuropeptide Y (NPY) signaling in the retinal pigment epithelium (RPE) by identifying the NPY receptor subtypes present, determining the effect of NPY on second-messenger production and membrane conductance, and establishing the neural retina as a site of NPY gene expression. METHODS Neuropeptide Y receptors present in bovine and human RPE were identi...

Neuropeptide Y (NPY), colocalized with norepinephrine neuron, is known to modulate sympathetic activity and feeding behavior. Although experimental type 1 diabetes has increased sympathetic activity at the early part of the disease process, little effort was made so far to understand the correlation between NPY level in the hypothalamus and sympathetic activity in diabetes. Male Sprague Dawley ...

Hwa, Joyce J., Melanie B. Witten, Patricia Williams, Lorraine Ghibaudi, Jun Gao, Brian G. Salisbury, Deborra Mullins, Fozia Hamud, Catherine D. Strader, and Eric M. Parker. Activation of the NPY Y5 receptor regulates both feeding and energy expenditure. Am. J. Physiol. 277 (Regulatory Integrative Comp. Physiol. 46): R1428–R1434, 1999.—Intracerebroventricular (ICV) administration of neuropeptide...

We read with interest Enman et al.'s recent publication on Neuropeptide Y (NPY) as a therapeutic target for stress-related psychiatric diseases (Enman et al., 2015). They observe that NPY has the potential to provide novel pharmacological therapy for stress-related psychiatric diseases and may have few peripheral side-effects and drugedrug interactions. Moreover, despite its short half-life, NP...

OBJECTIVE To investigate the role of mutations or polymorphisms in the NPY-Y1R gene in human idiopathic central pubertal disorders. DESIGN Molecular studies. SETTING University hospital. PATIENT(S) Thirty-three patients with gonadotropin-dependent precocious puberty, 22 with hypogonadotropic hypogonadism, and 50 controls. INTERVENTION(S) Genomic DNA extraction, NPY-Y1R gene sequence ana...