Several lines of evidence have suggested that iron is critical for Mycobacterium tuberculosis growth in macrophages. Macrophage iron loading in patients with African iron overload increases the risk of tuberculosis (TB) and may worsen TB outcome. Likewise, macrophage iron loading may contribute to an increased predisposition toward TB in HIV infection. Human genetic disorders or variations may ...

Salmonella enterica serovar Typhi can colonize the gallbladder and persist in an asymptomatic carrier state that is frequently associated with the presence of gallstones. We have shown that salmonellae form bile-mediated biofilms on human gallstones and cholesterol-coated surfaces in vitro. Here, we test the hypothesis that biofilms on cholesterol gallbladder stones facilitate typhoid carriage ...

Genetic resistance to Salmonella infection in experimental animal models is well described. However, genetic resistance in domestic animals, which has potentially great value in terms of controlling Salmonella in the food chain, has been relatively poorly described. Recent advances in genetics and immunology have identified several factors that influence resistance in chickens and pigs in parti...

Many genetic studies recently have focused on HLA, VDR, NRAMP1, MBL, TNF-a, and their relationships with susceptibility to diseases such as pulmonary tuberculosis. Some studies showed predisposing and protective roles for VDR polymorphisms in pulmonary tuberculosis. Through a case-control study, blood samples were taken from tuberculosis case (n= 164) and control (n= 50) groups. DNA was extract...

Brucella abortus in cattle 2 3 Running title: NRAMP1 3’UTR polymorphisms and brucellosis in cattle 4 5 Tatiane A. Paixão, Fernando P. Poester, Alcina V. Carvalho Neta, Álan M. Borges, 6 Andrey P. Lage, and Renato L. Santos* 7 8 1 Departamento de Clínica e Cirurgia Veterinária, 2 Departamento de Medicina Veterinária 9 Preventiva. Escola de Veterinária, Universidade Federal de Minas Gerais, 31270...