Dengue virus nonstructural protein 3 (NS3) unwinds double stranded RNA driven by the free energy derived from the hydrolysis of nucleoside triphosphates. This paper presents the first systematic and quantitative characterization of the steady-state NTPase activity of DENV NS3 and their interaction with ssRNA. Substrate curves for ATP, GTP, CTP and UTP were obtained, and the specificity order fo...

Background: This study aimed to propose an experiential approach for understanding color vision variation using virtual reality technology. Methods: The design was adapted from the phase 1 clinical trial medical apps. A classroom developed in a three-dimensional space, and ten healthy university students were tested understand vari...

Background: Infection after fracture fixation (IAFF) associated with an implant in orthopaedic surgery is a feared complication, leading to non-union, loss of function, amputation, and even mortality morbidity the patient. A biofilm formation on surface increases difficulty treatment. Therefore, surgical infection prevention effective antiseptic solution required. Th...

Background: Heating and cooling in buildings represents a significant amount of the energy demand EU, but market penetration renewable solutions is still marginal. The SunHorizon project aims at proving viability benefits innovative coupling between heat pumps various advanced solar panels. Methods:</...

Background: The opportunity to completely ‘stop biological time’ using cryopreservation, as it is used in embryo provides for the selection and long-term storage of high-quality preimplantation embryos future usage. While this a beneficial medical procedure, has however posed some legal issues such status an embryo, ownership reproductive autonomy, posthumous reprodu...

Background: Access to health services is needed around the world, from healthcare providers doctors. One of needs in public a system that accessible for everyone, but, unequal distribution provider and workers, especially dentistry fields still main problem several countries, including Indonesia. The aim this study analyze spatial dentists, dental technicians, therap...

Background: Doxorubicin is a crucial anticancer medication, however, cardiotoxicity severe adverse effect of doxorubicin therapy. Various mechanisms, including inflammation, have been postulated to account for this negative effect. The omega-7 fatty acid polyunsaturated with anti-inflammatory and antioxidant properties. Therefore, the study's objective was see whethe...

Background: The MUII mentorship programme began 11 years ago with a successful group model. Over the years, has evolved and is presently anchored on “GROW” approach. This model allows individuals to: set Goals (What I want?); Reflect (Where am now?); think of Options can do?)...

BACKGROUND Hepatitis C virus (HCV) effectively establishes persistent infection in human livers. The non-structural (NS) 3/4A complex participates in this process by cleavage of interferon beta (IFN beta) promoter stimulator-1 (IPS-1; also termed Cardif/MAVS/VISA), which inhibits responses to double stranded (ds) RNA. However, it is not known whether this effect extends beyond innate responses....

Background: Magnesium alloy is not only light in weight but also possesses moderate strength. AZ31-H24 sheet has many applications the automotive and aerospace industries. Experimental stretch forming tests are performed on this to measure material’s formability by constructing limit diagrams. Methods: Several of Nakazima were carr...