The ability of the nucleus pulposus of the intervertebral disc to resist compressive loads is due to its high content of the proteoglycan aggrecan. Degeneration of the intervertebral disc is preceded and accompanied by a loss of aggrecan due to proteolysis. Biological repair of intervertebral disc degeneration should strive to restore aggrecan content to its optimal functional level. One approa...

main reasons for workforce losses. Disc herniation is important as it both causes symptoms and requires prolonged treatment. Intervertebral discs are 23 formations existing between adjacent surfaces of the vertebral bodies from the axis to the sacrum.1 The area surrounding the nucleus pulposus consists of fibers, which include a number of chondrocytes. Therefore, the tissue is known as "fibroca...