By SIDNEY TRUBOWITZ, M.D. T HE OCCURRENCE of amyloidosis in multiple myeloma has been long recognized and the association of the two conditions well established. In 1931, Magnus-Levy’ wrote : ‘ ‘When I, at first purely out of interest in the clinical and metabolic aspects of myeloma, dug deeper into the literature, I was surprised to find a rather large, constantly growing body of data on amylo...

Effects of kainic acid lesions in the medullary raphe midline on reflex expirations induced mechanically from the trachea were examined. Spontaneously breathing rabbits were anesthetized by ketamine and xylazine i.m., followed by pentobarbitone i.v. Excitatory neurotoxin kainic acid (2 mg/ml in artificial CSF, total volume of 55-100 nl) was pressure microinjected into the medullary midline, ros...

Groups of pregnant rats were injected with two successive daily doses of 3H-thymidine from gestational days 12 and 13 (E12 + 13) until the day before birth (E21 + 22). In radiographs from adult progeny of these rats the proportion of neurons generated on specific days was determined in the major nuclei of the upper medulla, with the exception of the vestibular and auditory nuclei. The neurons o...

A wealth of pharmacological and behavioral data suggests that spinally projecting serotonergic cells mediate opioid analgesia. A population of medullary neurons, located within raphe magnus (RM) and the neighboring reticular nuclei, contains serotonin and is the source of serotonin in the spinal dorsal horn. To test whether serotonergic neurons mediate opioid analgesia, morphine was administere...

Recent evidence suggests that neurons in the medullary raphe are critical to the activation of brown adipose tissue (BAT), the major source of nonshivering heat production in the rat. Yet it is unclear which medullary raphe cells participate in cold defense and how participating cells contribute to BAT activation. Therefore, we recorded extracellularly from raphe cells during three thermoregula...

In this study, we characterized the role of delta-1 and delta-2 opioid receptors in the ventromedial medulla (VMM) in the modulation of thermal nociception. Male Sprague-Dawley rats were prepared with an intracerebral guide cannula aimed at the nucleus raphe magnus or nucleus reticularis gigantocellularis pars alpha. Microinjection of the delta-1 opioid receptor agonist [D-Pen2,D-Pen5]enkephali...

The three-dimensional structure of a tryptophan-containing variant of the IgG-binding B1 domain of protein L has been solved in two crystal forms to 1.7 and 1.8 A resolution. In one of the crystal forms, the entire N-terminal histidine-tag region was immobilized through the coordination of zinc ions and its structural conformation along with the zinc coordination scheme were determined. However...

Bumblebees are ecologically and economically important, and some species have suffered dramatic population declines. The absence of morphological diagnostic characters for the identification of some species creates difficulties for basic ecological studies, and for conservation management. The widespread and commercially exploited bumblebee subgenus ​Bombus sensu stricto​ contains a cryptic spe...

Hatim Alnoor, Chan Oeurn Chey, Galia Pozina, Xianjie Liu, Volodymyr Khranovskyy, Magnus Willander and Omer Nour, Effect of precursor solutions stirring on deep level defects concentration and spatial distribution in low temperature aqueous chemical synthesis of zinc oxide nanorods, 2015, AIP Advances, (5), 8. http://dx.doi.org/10.1063/1.4929981 Copyright: American Institute of Physics (AIP): Op...

The empirical evidence of adverse selection in insurance markets is mixed. The problem in assessing the extent of adverse selection is that insurance coverage also give rise to moral hazard. With private information— on which agents act— generally being unobservable to the researcher, is is di¢ cult to distinguish adverse selection from moral hazard. Unique micro data is here used to provide a ...