Ovarian cancer (OC) mostly arises sporadically, but a fraction of cases are associated with mutations in BRCA1 and BRCA2 genes. The presence of a BRCA mutation in OC patients has been suggested as a prognostic and predictive factor. In addition, the identification of asymptomatic carriers of such mutations offers an unprecedented opportunity for OC prevention. This review is aimed at exploring ...

introduction: nowadays,  considerable developments  in  the field  of  radiotherapy have  been  achieved.  they  include  the  advances  made  in  the  equipments  and  treatment  planning  techniques  which  require  highly complex calculations. such achievements have made it possible to treat cancer patients not only  with  higher  radiation  dose  but  also  with  higher  precision  and  con...

OBJECTIVE We hypothesized that DNA methylation of development-related genes may occur in endometrial cancer (EC)/ovarian cancer (OC) and may be detected in cervical scrapings. METHODS We tested methylation status by quantitative methylation-specific polymerase chain reaction for 14 genes in DNA pools of endometrial and OC tissues. Tissues of EC/normal endometrium, OC/normal ovary, were verifi...

We use a global 3-D model simulation of elemental carbon (EC) and organic carbon (OC) aerosols to interpret year-round observations for 1998 at a network of 45 U.S. sites (IMPROVE) and from there to better quantify the natural and anthropogenic U.S. sources of these aerosols. Our resulting best estimate of 1998 sources in the contiguous United States are 0.60 Tg yr EC and 0.52 Tg yr OC from fos...

Visual survey by divers using open-circuit (OC) SCUBA is the most widely used approach to survey coral reef fishes. Therefore, it is important to quantify sources of bias in OC surveys, such as the possibility that avoidance of OC divers by fishes can lead to undercounting in areas where targeted species have come to associate divers with a risk of being speared. One potential way to reduce div...

Hydroelectric reservoirs bury significant amounts of organic carbon (OC) in their sediments. Many reservoirs are characterized by high sedimentation rates, low oxygen concentrations in bottom water and a high share of terrestrially derived OC, and all of these factors have been linked to a high efficiency of OC burial. However, investigations of OC burial efficiency (OCBE, i.e., the ratio betwe...

Gamma-glutamyltransferase (GGT) is a marker for hepatic injury and alcohol consumption. However, the association of GGT with the risk of oesophageal carcinoma (OC) has not been fully recognized to date. Therefore, this study aimed to determine the association between elevated GGT and OC, by also considering the body mass index (BMI) of the subjects. Clinical data from 8,388,256 Korean individua...

Organochlorines (OC) are lipophilic and stable, and therefore accumulate in tissues of top predators, such as marine mammals. While the immunomodulatory effects of individual OC have been studied in lab animals, their effects in other species (such as marine mammals) and the possible interactions between chemicals in mixtures are not well understood. This study investigated the immunomodulatory...

This article presents two studies that examine the hypothesis that obsessive-compulsive (OC) tendencies are associated with a general deficiency in subjective conviction, which leads to seeking and reliance on external proxies to compensate for that deficiency. We examined this hypothesis using a biofeedback-aided relaxation procedure. In Study 1 low OC participants performed better on a relaxa...

BACKGROUND The memory deficit hypothesis has been used to explain the maintenance of repetitive behavior in individuals with obsessive-compulsive disorder, yet the majority of studies focusing on verbal memory show mixed results. These studies primarily evaluated memory accuracy via the inclusion or omission of previously encountered material, as opposed to false recognition (i.e., the inclusio...