The linear relative rate model has been employed in epidemiologic analyses of a variety of environmental and occupational exposures. In contrast to an exponential rate model, the linear relative rate model implies that the excess relative rate of disease changes in an additive fashion with exposure. The linear relative rate model may be fitted using EPICURE (HiroSoft International Corporation, ...

The expert method of exposure assignment involves relying on chemists or hygienists to estimate occupational exposures using information collected on study subjects. Once the estimation method for a particular contaminant has been made available in the literature, it is not known whether a non-expert, briefly trained by an expert remaining available to answer ad hoc questions, can provide relia...

Random error (misclassification) in exposure measurements usually biases a relative risk, regression coefficient, or other effect measure towards the null value (no association). The most important exception is Berkson type error, which causes little or no bias. Berkson type error arises, in particular, due to use of group average exposure in place of individual values. Random error in exposure...

While self-response to a checklist of substances may be a convenient and inexpensive method for obtaining information on occupational exposure, the validity of such information has not been evaluated. The objective of this report is to provide some evidence concerning validity of self-reported occupational exposures. In the context of a large case-control study, it was possible to compare self-...

OBJECTIVES To assess the accuracy with which workers report their exposure to occupational sources of hand transmitted (HTV) and whole body vibration (WBV). METHODS 179 Workers from various jobs involving exposure to HTV or WBV completed a self administered questionnaire about sources of occupational exposure to vibration in the past week. They were then observed at work over 1 hour, after wh...

The continuing increase in the worldwide use of X-ray imaging has implications for radiation protection of medical staff. Much of the increased usage could be viewed as simply a workload issue with no particular new challenges. However, advances in technology and developments in techniques have seen an increase in the number of X-ray procedures in which medical personnel need to maintain close ...

We have developed a computer code called BIOKMOD that we have applied to analyze several sources of uncertainties in the evaluation of internal exposures using bioassay data: (1) Multiple constant and random intakes in occupational exposures taking into account periods without intake (weekends, holidays, etc.) are evaluated, and they are compared with chronic intakes showing that the chronic ap...

The epidemiology of multiple sclerosis (MS) has been intensively studied. It is conceptualised as a complex disease in which genetic and environmental factors act together to cause disease. There are temporal and geographic variations in disease risk, and risk of disease may be affected by migration between regions of differing risk. Numerous potential causal factors including infection, immuni...

OBJECTIVES Most of the evidence on agreement between self- and proxy-reported occupational data comes from interview-based studies. The authors aimed to examine agreement between women's reports of their partner's occupation and their partner's own description using questionnaire-based data collected as a part of the prospective, population-based Avon Longitudinal Study of Parents and Children....