Gas chromatography in combination with mass spectrometry (GC-MS) plays an important role in the field of analytical toxicology. The identification of unknown compounds is very frequently undertaken with GC-MS and utilizing mass spectral libraries. Currently available libraries for analytical toxicology were compared for overlapping and uniqueness of their entries. Furthermore, the widely known ...

N,N-Dimethylformamide (DMF) is globally used as an organic solvent in the production of synthetic leather and resins because of its low volatility, making it an attractive industrial material. Despite its excellent property as a chemical solvent, utilization of DMF is somewhat controversial nowadays due to its hazardous effects on exposed workers in work places. Many toxification cases are bein...

background: copper is a trace element vital to life, but the toxic effect of water pollution with it on fish is now exhibited. fish blood is susceptible to contamination-induced stress and its alternation due to the hematological and immunological parameters can be utilized as toxicity indices of xenobiotics. methods: in this study, juvenile species of silver carp with average weight of 200gr w...

nanotechnology is a rapidly growing field having potential applications in many areas. nanoparticles (nps) have been studied for cell toxicity, immunotoxicity, and genotoxicity. tetrazolium-based assays such as mtt, mts, and wst-1 are used to determine cell viability. cell inflammatory response induced by nps is checked by measuring inflammatory biomarkers, such as il-8, il-6, and tumor necrosi...

Predictive toxicology plays an important role in the assessment of toxicity of chemicals and the drug development process. While there are several well-established in vitro and in vivo assays that are suitable for predictive toxicology, recent advances in high-throughput analytical technologies and model systems are expected to have a major impact on the field of predictive toxicology. This com...

In Vitro Toxicology Society Annual Meeting November 10–11, 2015 Birmingham, United Kingdom These abstracts were presented at the 2015 annual meeting of the UK In Vitro Toxicology Society (IVTS). The meeting was hosted at Birmingham, UK on November 10–11, 2015. The main session topics included hepatoxicology, inhalation toxicology, developmental and reproductive toxicology, and neurotoxicology. ...

Concerns that chemical exposures in the environment have been detrimental to male sexual development and fertility have been heightened by reports of declining sperm counts over the past 50 years. Marked geographic variation has been found in semen quality and in the incidence of testicular cancer and certain urogenital defects. Debate continues over the existence, magnitude and significance of...

Hair testing for drugs of abuse is a developing technology, which offers the possibility of longer detection times than is commonly obtained with urine analysis. It is the main method for evaluation of an individual's drugs of abuse history. In many countries hair analysis is routinely used to detect drug abuse in forensic cases, occupational and traffic medicine and clinical toxicology. Hair a...

Exposure to low-toxicity dusts, which have previously been viewed as 'nuisance dusts', can cause chronic obstructive pulmonary disease or other nonmalignant respiratory disease. In Britain, the 'de facto' airborne exposure limits for these dusts have remained unchanged for >30 years; currently, they are 10mg m(-3) for inhalable dust and 4mg m(-3) for respirable dust. During this time, exposures...