BACKGROUND AND OBJECTIVES Many patients with type 2 diabetes mellitus (T2DM) do not achieve glycaemic control targets on basal insulin regimens. This analysis investigated characteristics, clinical outcomes and impact of concomitant oral antidiabetes drugs (OADs) in patients with T2DM treated with high-dose insulin glargine. METHODS Patient-level data were pooled from 15 randomised, treat-to-...

OBJECTIVE To determine the prevalence and factors associated with overweight/obesity among adults in Ho Chi Minh City (HCMC) using Caucasian and Asian cut-offs. STUDY DESIGN A cross-sectional survey. METHODS In 2005, 1,971 adults aged 25-64 years in HCMC were randomly selected using a proportional to population size sampling method to estimate the prevalence of overweight and obesity, measu...

Trade-offs between immune function and reproduction are common to many organisms. Nevertheless, high energetic resources may eliminate the need for these trade-offs. In this study, we consider the effects of food availability on these trade-offs in a wild population of female sagebrush lizards (Sceloporus graciosus) during the breeding season. We manipulated food availability by supplementing s...

T his special issue addresses the business of producing computing machines and the choices computer architects and implementors must make to succeed in the marketplace. This focus represents the sober reflection that computer architecture is not yet a science, even though parts of the discipline can be considered science and most of it often involves scientific methodology. To a large extent, t...

The front cover describes the subject of the book as the manoeuvres and stratagems by which men, women and children deceive, compete , conflict, manipulate, make love and annihilate each other.

Replicated systems provide the foundation for most of today’s large-scale services. Engineering such replicated system is an onerous task. The first—and often foremost—step in this task is to establish an appropriate set of design goals, such as availability or performance, which should synthesize all the underlying system properties. Mixing design goals, however, is fraught with dangers, given...

Trait exaggeration through sexual selection will tale place alongside other changes in phenotype. Exaggerated morphology might be compensated by parallel changes in traits that support, enhance or facilitate exaggeration: 'secondary sexual trait compensation' (SSTC). Alternatively, exaggeration might be realized at the expense of other traits through morphological trade-offs. For the most part,...

Dramatic changes in ecosystem services have motivated recent work characterizing their interactions, including identifying trade-offs and synergies. Although time is arguably implicit in these ideas of trade-offs and synergies (e.g., temporal dynamics or changes in ecosystem services), such interactions are routinely inferred based on the spatial relationships among ecosystem services alone (e....

In this paper, we explore factors that may determine the performance of university spin-off companies. In particular, we focus on socioeconomic networks and support received from incubator organizations. Using spin-offs from the Technical University of Delft, the Netherlands as a case study, we explore whether spin-offs’ performance is influenced by the characteristics of their networks, i.e. t...