Rats with 6-hydroxydopamine (6-OHDA) lesions of the nigrostriatal pathway show enhanced locomotor and stereotyped behaviors when challenged with direct and indirect dopamine (DA) agonists due to the development of postsynaptic supersensitivity. To determine if this phenomenon generalizes to other motor behaviors, we have used this rat model of Parkinson's disease to examine the effects of the d...

A unilateral lesion of the rat nigrostriatal pathway with 6-hydroxydopamine (6-OHDA) results in a decrease in the basal extracellular level of striatal glutamate, a nearly complete loss of tyrosine hydroxylase (TH) immunolabeling, an increase in the density of glutamate immunogold labeling within nerve terminals making an asymmetrical synaptic contact, and an increase in the number of apomorphi...

Neurodegenerative diseases like Parkinson’s disease (PD),Amyotrophic Lateral Sclerosis (ALS) and Schizophrenia are a group of illness with diverse clinical importance and etiologies. Oxidative stress in which production of highly reactive oxygen species (ROS) and reactive nitrogen species (RNS) overwhelms antioxidant defences, is a feature of many neurological diseases. Lycopene, the most poten...

Parkinson’s disease (PD) is characterized by progressive dopaminergic neuron loss or dysfunction and the second most prevalent neurodegenerative disorder after Alzheimer’s disease. However, current therapeutic strategies for PD are limited to treating outcomes of this rather than preventing it. Sinapic acid (SA) a phenolic compound with potential antioxidant properties, which reportedly acts as...

Background and Purpose Microglia-related inflammation is associated with the pathology of Parkinson's disease. Functional voltage-gated sodium channels (VGSCs) are involved in regulating microglial function. Here, we aim to investigate effects scorpion venom heat-resistant synthesized peptide (SVHRSP) on 6-hydroxydopamine (6-OHDA)-induced disease-like mouse model reveal its underlying mechanism...

Increased oxidative stress in the human brain is observed neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s (AD), considered to be a major cause of progression these states. A very long-chain fatty acid, nervonic acid (NA), main found various sphingolipid species central nervous system. NA plays an important role forming plasma membrane’s lipid bilayer maintaining norm...

The neuroprotective effects of environmental enrichment and PACAP (pituitary adenylate cyclase-activating polypeptide) are well-described in Parkinson’s disease. aim our study is to investigate the beneficial these factors aging parkinsonian rats. Newborn Wistar rats were divided into standard enriched groups according their conditions. Standard animals raised under regular During first five po...

The G-protein coupled receptor 139 (GPR139) is expressed specifically in the brain in areas of relevance for motor control. GPR139 function and signal transduction pathways are elusive, and results in the literature are even contradictory. Here, we examined the potential neuroprotective effect of GPR139 agonism in primary culture models of dopaminergic (DA) neuronal degeneration. We find that i...